REE1_YEAST
ID REE1_YEAST Reviewed; 198 AA.
AC P40893; D6VVX9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Regulation of enolase protein 1;
GN Name=REE1; OrderedLocusNames=YJL217W; ORFNames=HRC198, J0226;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7725802; DOI=10.1002/yea.320101216;
RA Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.;
RT "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere
RT of yeast chromosome X.";
RL Yeast 10:1657-1662(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP INDUCTION.
RX PubMed=10922376; DOI=10.1074/jbc.m005946200;
RA Gross C., Kelleher M., Iyer V.R., Brown P.O., Winge D.R.;
RT "Identification of the copper regulon in Saccharomyces cerevisiae by DNA
RT microarrays.";
RL J. Biol. Chem. 275:32310-32316(2000).
RN [6]
RP INDUCTION.
RX PubMed=12161108; DOI=10.1016/s0143-4160(02)00110-0;
RA Lombardia L.J., Becerra M., Rodriguez-Belmonte E., Hauser N.C.,
RA Cerdan M.E.;
RT "Genome-wide analysis of yeast transcription upon calcium shortage.";
RL Cell Calcium 32:83-91(2002).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [8]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [9]
RP INDUCTION, INTERACTION WITH GAL83, AND FUNCTION.
RX PubMed=18851946; DOI=10.1016/j.bbrc.2008.09.146;
RA Choi I.D., Jeong M.Y., Ham M.S., Sung H.C., Yun C.W.;
RT "Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway
RT in Saccharomyces cerevisiae.";
RL Biochem. Biophys. Res. Commun. 377:395-399(2008).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).
RG Midwest center for structural genomics (MCSG);
RT "The crystal structure of a functionally unknown protein from saccharomyces
RT cerevisiae.";
RL Submitted (SEP-2010) to the PDB data bank.
CC -!- FUNCTION: Functions in the galactose metabolic pathway via the GAL83
CC protein and that it may control the level of ENO1.
CC {ECO:0000269|PubMed:18851946}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC -!- INDUCTION: By calcium shortage, copper deficiency (via MAC1) and the
CC presence of galactose (via GAL4). {ECO:0000269|PubMed:10922376,
CC ECO:0000269|PubMed:12161108, ECO:0000269|PubMed:18851946}.
CC -!- MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z34098; CAA83993.1; -; Genomic_DNA.
DR EMBL; Z49492; CAA89514.1; -; Genomic_DNA.
DR EMBL; AY558254; AAS56580.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08595.1; -; Genomic_DNA.
DR PIR; S50710; S50710.
DR RefSeq; NP_012318.1; NM_001181650.1.
DR PDB; 3O12; X-ray; 1.50 A; A=1-198.
DR PDBsum; 3O12; -.
DR AlphaFoldDB; P40893; -.
DR SMR; P40893; -.
DR BioGRID; 33564; 47.
DR MINT; P40893; -.
DR STRING; 4932.YJL217W; -.
DR iPTMnet; P40893; -.
DR MaxQB; P40893; -.
DR PaxDb; P40893; -.
DR PRIDE; P40893; -.
DR DNASU; 853238; -.
DR EnsemblFungi; YJL217W_mRNA; YJL217W; YJL217W.
DR GeneID; 853238; -.
DR KEGG; sce:YJL217W; -.
DR SGD; S000003753; REE1.
DR VEuPathDB; FungiDB:YJL217W; -.
DR eggNOG; ENOG502RZMY; Eukaryota.
DR GeneTree; ENSGT00390000013865; -.
DR HOGENOM; CLU_082825_0_0_1; -.
DR InParanoid; P40893; -.
DR OMA; GLMVRID; -.
DR BioCyc; YEAST:G3O-31642-MON; -.
DR PRO; PR:P40893; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P40893; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009784; DUF1349.
DR InterPro; IPR015987; UCP022704.
DR PANTHER; PTHR35332; PTHR35332; 1.
DR Pfam; PF07081; DUF1349; 1.
DR PIRSF; PIRSF022704; UCP022704; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..198
FT /note="Regulation of enolase protein 1"
FT /id="PRO_0000203011"
FT HELIX 9..11
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 13..16
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 19..24
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 27..31
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:3O12"
FT TURN 42..44
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 47..49
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 51..57
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 60..70
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 78..86
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 89..98
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 101..119
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 126..134
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 137..147
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 151..156
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 164..170
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:3O12"
FT STRAND 178..187
FT /evidence="ECO:0007829|PDB:3O12"
SQ SEQUENCE 198 AA; 21967 MW; 52F6BE7CEA722D37 CRC64;
MVESKNTELS QGTWLNKPKS VFQEAGKVTL ETDEKTDFWR ETFYGFTRDS GHFLGVETGS
AFTAQVRVQG SYESLYDQAG IMVRIDDGHW LKAGIEISDG HAMLSSVLTN GKSDWSTAVY
GGNARDFWLR VTVEKGVLRI QVSSDKKTWP LVRLAPFPTS DHYLVGPMAC TPERGGLKVT
FSEWSLTAPL GKALHDLS
