ID   REEP2_BOVIN             Reviewed;         254 AA.
AC   Q2KI30;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Receptor expression-enhancing protein 2;
GN   Name=REEP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for endoplasmic reticulum (ER) network formation,
CC       shaping and remodeling. May enhance the cell surface expression of
CC       odorant receptors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with odorant receptor proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC112790; AAI12791.1; -; mRNA.
DR   RefSeq; NP_001039790.1; NM_001046325.2.
DR   AlphaFoldDB; Q2KI30; -.
DR   STRING; 9913.ENSBTAP00000013281; -.
DR   PaxDb; Q2KI30; -.
DR   PRIDE; Q2KI30; -.
DR   Ensembl; ENSBTAT00000013281; ENSBTAP00000013281; ENSBTAG00000010068.
DR   GeneID; 532432; -.
DR   KEGG; bta:532432; -.
DR   CTD; 51308; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010068; -.
DR   VGNC; VGNC:33852; REEP2.
DR   eggNOG; KOG1726; Eukaryota.
DR   GeneTree; ENSGT00940000160001; -.
DR   HOGENOM; CLU_028431_0_1_1; -.
DR   InParanoid; Q2KI30; -.
DR   OMA; GILCARE; -.
DR   OrthoDB; 1473891at2759; -.
DR   TreeFam; TF314177; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000010068; Expressed in floor plate of diencephalon and 105 other tissues.
DR   ExpressionAtlas; Q2KI30; baseline and differential.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0031883; F:taste receptor binding; IBA:GO_Central.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..254
FT                   /note="Receptor expression-enhancing protein 2"
FT                   /id="PRO_0000244384"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          164..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VCD6"
SQ   SEQUENCE   254 AA;  28440 MW;  877657DB7F7DB005 CRC64;
     MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIVLS
     WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR
     VGKRGLNLAA NAAVTAAAKG QGVLSEKLRS FSMQDLTLIR DEDALPLQGP DGRLRASPGS
     LLDTIEDLGD DPTLSVRSGT NQADPRTEIS EDDTGDKAPK RVKPIKKVPK PEPPASKTLK
     TRPKKKTSAG GDSA