ID   REEP2_DANRE             Reviewed;         268 AA.
AC   Q4KMI4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Receptor expression-enhancing protein 2;
GN   Name=reep2; ORFNames=zgc:110128;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May enhance the cell surface expression of odorant receptors.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with odorant receptor proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC098549; AAH98549.1; -; mRNA.
DR   RefSeq; NP_001025398.1; NM_001030227.1.
DR   AlphaFoldDB; Q4KMI4; -.
DR   SMR; Q4KMI4; -.
DR   STRING; 7955.ENSDARP00000043161; -.
DR   PaxDb; Q4KMI4; -.
DR   GeneID; 568927; -.
DR   KEGG; dre:568927; -.
DR   CTD; 51308; -.
DR   ZFIN; ZDB-GENE-050706-125; reep2.
DR   eggNOG; KOG1726; Eukaryota.
DR   InParanoid; Q4KMI4; -.
DR   OrthoDB; 1473891at2759; -.
DR   PhylomeDB; Q4KMI4; -.
DR   PRO; PR:Q4KMI4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0031883; F:taste receptor binding; IBA:GO_Central.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..268
FT                   /note="Receptor expression-enhancing protein 2"
FT                   /id="PRO_0000101825"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          170..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30110 MW;  42044544DAAFA16F CRC64;
     MVSWIISRMV VLAFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFALFTT AETITDMLLS
     WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE REIDEYITQA KDRSYDTMMR
     FGRRGLNIAA TAAVTAATKG QGVLSEKLRS FSMQDLTLIQ NEDELQLEGG DDTHTAATLP
     RAKTATRTVR ATPVPADTES QHSSRSDDQS DSRTEHSDED AADKAPKRIA ITRAAKKPAA
     AKTEQTTKTV KKAPKKKPTT ANNVAESP