REEP2_MOUSE
ID REEP2_MOUSE Reviewed; 254 AA.
AC Q8VCD6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Receptor expression-enhancing protein 2;
GN Name=Reep2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for endoplasmic reticulum (ER) network formation,
CC shaping and remodeling. May enhance the cell surface expression of
CC odorant receptors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with odorant receptor proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR EMBL; AY562230; AAT70675.1; -; mRNA.
DR EMBL; BC020184; AAH20184.2; -; mRNA.
DR CCDS; CCDS29135.1; -.
DR RefSeq; NP_001191843.1; NM_001204914.1.
DR RefSeq; NP_659114.2; NM_144865.2.
DR AlphaFoldDB; Q8VCD6; -.
DR IntAct; Q8VCD6; 1.
DR MINT; Q8VCD6; -.
DR STRING; 10090.ENSMUSP00000036065; -.
DR iPTMnet; Q8VCD6; -.
DR PhosphoSitePlus; Q8VCD6; -.
DR MaxQB; Q8VCD6; -.
DR PaxDb; Q8VCD6; -.
DR PRIDE; Q8VCD6; -.
DR ProteomicsDB; 255282; -.
DR ABCD; Q8VCD6; 2 sequenced antibodies.
DR Antibodypedia; 26670; 428 antibodies from 27 providers.
DR DNASU; 225362; -.
DR Ensembl; ENSMUST00000043484; ENSMUSP00000036065; ENSMUSG00000038555.
DR GeneID; 225362; -.
DR KEGG; mmu:225362; -.
DR UCSC; uc008elr.2; mouse.
DR CTD; 51308; -.
DR MGI; MGI:2385070; Reep2.
DR VEuPathDB; HostDB:ENSMUSG00000038555; -.
DR eggNOG; KOG1726; Eukaryota.
DR GeneTree; ENSGT00940000160001; -.
DR HOGENOM; CLU_028431_0_1_1; -.
DR InParanoid; Q8VCD6; -.
DR OMA; GILCARE; -.
DR OrthoDB; 1473891at2759; -.
DR PhylomeDB; Q8VCD6; -.
DR TreeFam; TF314177; -.
DR BioGRID-ORCS; 225362; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Reep2; mouse.
DR PRO; PR:Q8VCD6; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8VCD6; protein.
DR Bgee; ENSMUSG00000038555; Expressed in animal zygote and 152 other tissues.
DR Genevisible; Q8VCD6; MM.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0031883; F:taste receptor binding; IPI:MGI.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR GO; GO:0032596; P:protein transport into membrane raft; IDA:MGI.
DR GO; GO:0032386; P:regulation of intracellular transport; IDA:UniProtKB.
DR GO; GO:0050913; P:sensory perception of bitter taste; IGI:MGI.
DR GO; GO:0050916; P:sensory perception of sweet taste; IGI:MGI.
DR InterPro; IPR004345; TB2_DP1_HVA22.
DR PANTHER; PTHR12300; PTHR12300; 1.
DR Pfam; PF03134; TB2_DP1_HVA22; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..254
FT /note="Receptor expression-enhancing protein 2"
FT /id="PRO_0000101824"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 194..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 254 AA; 28437 MW; 63F9770A04B122AC CRC64;
MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIILS
WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR
VGKRGLNLAA NAAVTAAAKG QGVLSEKLRS FSMQDLTLIR DEDALPLQGP DGRLQPGPVG
LLDTIEDLGD EPALSLRSST SQPDPRTETS EDDLGDKAPK RTKPIKKVPR AEPPASKTLK
TRPKKKSSGG GDSA
