ID   REEP3_DANRE             Reviewed;         256 AA.
AC   Q7ZVX5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Receptor expression-enhancing protein 3;
GN   Name=reep3; ORFNames=zgc:55529;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC       division and nuclear envelope reassembly by sequestering the
CC       endoplasmic reticulum away from chromosomes during mitosis. Probably
CC       acts by clearing the endoplasmic reticulum membrane from metaphase
CC       chromosomes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC045373; AAH45373.1; -; mRNA.
DR   RefSeq; NP_956455.1; NM_200161.1.
DR   AlphaFoldDB; Q7ZVX5; -.
DR   STRING; 7955.ENSDARP00000023124; -.
DR   PaxDb; Q7ZVX5; -.
DR   Ensembl; ENSDART00000021628; ENSDARP00000023124; ENSDARG00000004160.
DR   GeneID; 393130; -.
DR   KEGG; dre:393130; -.
DR   CTD; 393130; -.
DR   ZFIN; ZDB-GENE-040426-730; reep3b.
DR   eggNOG; KOG1726; Eukaryota.
DR   GeneTree; ENSGT00940000158794; -.
DR   HOGENOM; CLU_028431_0_1_1; -.
DR   InParanoid; Q7ZVX5; -.
DR   OMA; DLTISWF; -.
DR   OrthoDB; 1473891at2759; -.
DR   PhylomeDB; Q7ZVX5; -.
DR   TreeFam; TF314177; -.
DR   PRO; PR:Q7ZVX5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000004160; Expressed in zone of skin and 31 other tissues.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR   GO; GO:0007084; P:mitotic nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Endoplasmic reticulum; Membrane; Microtubule;
KW   Mitosis; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..256
FT                   /note="Receptor expression-enhancing protein 3"
FT                   /id="PRO_0000101828"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          177..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   256 AA;  29222 MW;  EE18D191E486EDA0 CRC64;
     MVSWMISRSV VLVFGNLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALFTV VETVADLTIA
     WFPLYYEIKI AFVIWLLSPY TRGASVIYRK ALHPLLSSKE REIDDYIVQA KERSYETMVN
     FGKQGLTIAA TAAVSAAVKG QGAITEKLRS FSMHDLTQIP QDDGYSSYAS NPARRAIMDQ
     PDGAEYYHGD DDDRSDEDSK PVFSEDEAVS HHGLRRSQSV KVTRSKLRRD ARYGSLKIKG
     RKRPGINATT YSNMES