ID   REEP4_BOVIN             Reviewed;         257 AA.
AC   Q3ZCI8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Receptor expression-enhancing protein 4;
GN   Name=REEP4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC       division and nuclear envelope reassembly by sequestering the
CC       endoplasmic reticulum away from chromosomes during mitosis. Probably
CC       acts by clearing the endoplasmic reticulum membrane from metaphase
CC       chromosomes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC102171; AAI02172.1; -; mRNA.
DR   RefSeq; NP_001029705.1; NM_001034533.2.
DR   AlphaFoldDB; Q3ZCI8; -.
DR   STRING; 9913.ENSBTAP00000012505; -.
DR   PaxDb; Q3ZCI8; -.
DR   PRIDE; Q3ZCI8; -.
DR   GeneID; 519613; -.
DR   KEGG; bta:519613; -.
DR   CTD; 80346; -.
DR   eggNOG; KOG1726; Eukaryota.
DR   HOGENOM; CLU_028431_0_1_1; -.
DR   InParanoid; Q3ZCI8; -.
DR   OrthoDB; 1473891at2759; -.
DR   TreeFam; TF314177; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR   GO; GO:0007084; P:mitotic nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Endoplasmic reticulum; Membrane; Microtubule;
KW   Mitosis; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Receptor expression-enhancing protein 4"
FT                   /id="PRO_0000101829"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          159..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6H4"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6H4"
FT   MOD_RES         196
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6H4"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6H4"
FT   MOD_RES         250
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6H4"
FT   MOD_RES         253
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6H4"
SQ   SEQUENCE   257 AA;  29597 MW;  E8CEDD9418984DBF CRC64;
     MVSWMICRLV VLVFGMLYPA YASYKAVKTK NIREYVRWMM YWIVFALFMA VETFTDIFIS
     WFPFYYEIKM AFVLWLLSPY TRGASMLYRK FVHPSLSRHE KEIDTYIVQA KERSYETVLS
     FGKRGLNIAA SAAVQAATKS QGALAGKLRS FSMQDLRTIP DGPAPTYQDP LYLEDQVPHR
     RPPIGYRAGG LRDSDTDNEC WSDTEVVPQP PARPREKPLG RSQSLRVIKR KPLAREGTSR
     SLKVRTRKKT APSDMDS