REEP4_HUMAN
ID REEP4_HUMAN Reviewed; 257 AA.
AC Q9H6H4; D3DSQ9; Q86VL1; Q9H6I5; Q9HBP4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Receptor expression-enhancing protein 4;
GN Name=REEP4; Synonyms=C8orf20; ORFNames=PP432;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Ovary, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=16720576; DOI=10.1074/jbc.m513637200;
RA Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.;
RT "Members of RTP and REEP gene families influence functional bitter taste
RT receptor expression.";
RL J. Biol. Chem. 281:20650-20659(2006).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-194; THR-196;
RP SER-202; THR-250 AND SER-253, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [13]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=23911198; DOI=10.1016/j.devcel.2013.06.016;
RA Schlaitz A.L., Thompson J., Wong C.C., Yates J.R. III, Heald R.;
RT "REEP3/4 ensure endoplasmic reticulum clearance from metaphase chromatin
RT and proper nuclear envelope architecture.";
RL Dev. Cell 26:315-323(2013).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [15]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC division and nuclear envelope reassembly by sequestering the
CC endoplasmic reticulum away from chromosomes during mitosis. Probably
CC acts by clearing the endoplasmic reticulum membrane from metaphase
CC chromosomes. {ECO:0000269|PubMed:23911198}.
CC -!- INTERACTION:
CC Q9H6H4; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-7545592, EBI-1754287;
CC Q9H6H4; P27449: ATP6V0C; NbExp=3; IntAct=EBI-7545592, EBI-721179;
CC Q9H6H4; Q07817: BCL2L1; NbExp=3; IntAct=EBI-7545592, EBI-78035;
CC Q9H6H4; O15155: BET1; NbExp=3; IntAct=EBI-7545592, EBI-749204;
CC Q9H6H4; Q13323: BIK; NbExp=3; IntAct=EBI-7545592, EBI-700794;
CC Q9H6H4; O95393: BMP10; NbExp=3; IntAct=EBI-7545592, EBI-3922513;
CC Q9H6H4; P09871: C1S; NbExp=3; IntAct=EBI-7545592, EBI-2810045;
CC Q9H6H4; O14523: C2CD2L; NbExp=3; IntAct=EBI-7545592, EBI-12822627;
CC Q9H6H4; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-7545592, EBI-12003442;
CC Q9H6H4; Q06432: CACNG1; NbExp=3; IntAct=EBI-7545592, EBI-9686780;
CC Q9H6H4; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-7545592, EBI-10271156;
CC Q9H6H4; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-7545592, EBI-11959453;
CC Q9H6H4; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-7545592, EBI-7247651;
CC Q9H6H4; P21964: COMT; NbExp=3; IntAct=EBI-7545592, EBI-372265;
CC Q9H6H4; O43169: CYB5B; NbExp=3; IntAct=EBI-7545592, EBI-1058710;
CC Q9H6H4; P00387: CYB5R3; NbExp=3; IntAct=EBI-7545592, EBI-1046040;
CC Q9H6H4; P78329: CYP4F2; NbExp=3; IntAct=EBI-7545592, EBI-1752413;
CC Q9H6H4; Q96PD2-2: DCBLD2; NbExp=3; IntAct=EBI-7545592, EBI-12135455;
CC Q9H6H4; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-7545592, EBI-398977;
CC Q9H6H4; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-7545592, EBI-12831978;
CC Q9H6H4; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-7545592, EBI-8639143;
CC Q9H6H4; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-7545592, EBI-711490;
CC Q9H6H4; Q96D05-2: FAM241B; NbExp=3; IntAct=EBI-7545592, EBI-12118888;
CC Q9H6H4; Q01740: FMO1; NbExp=3; IntAct=EBI-7545592, EBI-12701460;
CC Q9H6H4; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-7545592, EBI-714482;
CC Q9H6H4; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-7545592, EBI-11991950;
CC Q9H6H4; P06028: GYPB; NbExp=3; IntAct=EBI-7545592, EBI-10194756;
CC Q9H6H4; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-7545592, EBI-3918847;
CC Q9H6H4; Q9BUP3-3: HTATIP2; NbExp=3; IntAct=EBI-7545592, EBI-12937691;
CC Q9H6H4; Q01628: IFITM3; NbExp=3; IntAct=EBI-7545592, EBI-7932862;
CC Q9H6H4; P11215: ITGAM; NbExp=3; IntAct=EBI-7545592, EBI-2568251;
CC Q9H6H4; Q68G75: LEMD1; NbExp=3; IntAct=EBI-7545592, EBI-12268900;
CC Q9H6H4; Q9Y2U8: LEMD3; NbExp=3; IntAct=EBI-7545592, EBI-2561428;
CC Q9H6H4; O95214: LEPROTL1; NbExp=3; IntAct=EBI-7545592, EBI-750776;
CC Q9H6H4; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-7545592, EBI-12133176;
CC Q9H6H4; Q969L2: MAL2; NbExp=3; IntAct=EBI-7545592, EBI-944295;
CC Q9H6H4; O75425: MOSPD3; NbExp=3; IntAct=EBI-7545592, EBI-12179105;
CC Q9H6H4; P11836: MS4A1; NbExp=3; IntAct=EBI-7545592, EBI-2808234;
CC Q9H6H4; O43639: NCK2; NbExp=3; IntAct=EBI-7545592, EBI-713635;
CC Q9H6H4; Q8N912: NRAC; NbExp=3; IntAct=EBI-7545592, EBI-12051377;
CC Q9H6H4; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-7545592, EBI-1054848;
CC Q9H6H4; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-7545592, EBI-981985;
CC Q9H6H4; Q04941: PLP2; NbExp=3; IntAct=EBI-7545592, EBI-608347;
CC Q9H6H4; Q01453: PMP22; NbExp=3; IntAct=EBI-7545592, EBI-2845982;
CC Q9H6H4; Q59EV6: PPGB; NbExp=3; IntAct=EBI-7545592, EBI-14210385;
CC Q9H6H4; O60831: PRAF2; NbExp=3; IntAct=EBI-7545592, EBI-2506064;
CC Q9H6H4; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-7545592, EBI-10244780;
CC Q9H6H4; Q96DX8: RTP4; NbExp=3; IntAct=EBI-7545592, EBI-12275482;
CC Q9H6H4; O75396: SEC22B; NbExp=3; IntAct=EBI-7545592, EBI-1058865;
CC Q9H6H4; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-7545592, EBI-9679163;
CC Q9H6H4; Q8WWX9: SELENOM; NbExp=3; IntAct=EBI-7545592, EBI-10277687;
CC Q9H6H4; O75920: SERF1B; NbExp=3; IntAct=EBI-7545592, EBI-2115181;
CC Q9H6H4; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-7545592, EBI-10329948;
CC Q9H6H4; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-7545592, EBI-2854842;
CC Q9H6H4; O95562: SFT2D2; NbExp=3; IntAct=EBI-7545592, EBI-4402330;
CC Q9H6H4; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-7545592, EBI-355861;
CC Q9H6H4; Q96NB2: SFXN2; NbExp=3; IntAct=EBI-7545592, EBI-6381136;
CC Q9H6H4; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-7545592, EBI-14193895;
CC Q9H6H4; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-7545592, EBI-10281975;
CC Q9H6H4; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-7545592, EBI-10262251;
CC Q9H6H4; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-7545592, EBI-13292283;
CC Q9H6H4; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-7545592, EBI-10226799;
CC Q9H6H4; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-7545592, EBI-12188413;
CC Q9H6H4; Q14534: SQLE; NbExp=3; IntAct=EBI-7545592, EBI-3905171;
CC Q9H6H4; P02808: STATH; NbExp=3; IntAct=EBI-7545592, EBI-738687;
CC Q9H6H4; Q13277: STX3; NbExp=3; IntAct=EBI-7545592, EBI-1394295;
CC Q9H6H4; Q13190: STX5; NbExp=3; IntAct=EBI-7545592, EBI-714206;
CC Q9H6H4; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-7545592, EBI-1049004;
CC Q9H6H4; Q9Y584: TIMM22; NbExp=3; IntAct=EBI-7545592, EBI-1200494;
CC Q9H6H4; Q9BXJ8: TMEM120A; NbExp=3; IntAct=EBI-7545592, EBI-727322;
CC Q9H6H4; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-7545592, EBI-10171534;
CC Q9H6H4; Q9BTD3: TMEM121; NbExp=3; IntAct=EBI-7545592, EBI-12155101;
CC Q9H6H4; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-7545592, EBI-10694905;
CC Q9H6H4; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-7545592, EBI-17684533;
CC Q9H6H4; Q96B42-2: TMEM18; NbExp=3; IntAct=EBI-7545592, EBI-17196383;
CC Q9H6H4; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-7545592, EBI-741829;
CC Q9H6H4; Q8N511: TMEM199; NbExp=3; IntAct=EBI-7545592, EBI-10265825;
CC Q9H6H4; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-7545592, EBI-12876824;
CC Q9H6H4; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-7545592, EBI-12195227;
CC Q9H6H4; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-7545592, EBI-11956809;
CC Q9H6H4; O95807: TMEM50A; NbExp=3; IntAct=EBI-7545592, EBI-12903814;
CC Q9H6H4; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-7545592, EBI-726044;
CC Q9H6H4; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-7545592, EBI-2852148;
CC Q9H6H4; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-7545592, EBI-6656213;
CC Q9H6H4; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-7545592, EBI-12015604;
CC Q9H6H4; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-7545592, EBI-11724433;
CC Q9H6H4; Q9Y320: TMX2; NbExp=3; IntAct=EBI-7545592, EBI-6447886;
CC Q9H6H4; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-7545592, EBI-17249488;
CC Q9H6H4; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-7545592, EBI-12003468;
CC Q9H6H4; O60636: TSPAN2; NbExp=3; IntAct=EBI-7545592, EBI-3914288;
CC Q9H6H4; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-7545592, EBI-11343401;
CC Q9H6H4; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-7545592, EBI-988826;
CC Q9H6H4; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-7545592, EBI-2819725;
CC Q9H6H4; Q53HI1: UNC50; NbExp=3; IntAct=EBI-7545592, EBI-7601760;
CC Q9H6H4; P23763-3: VAMP1; NbExp=3; IntAct=EBI-7545592, EBI-12097582;
CC Q9H6H4; O75379: VAMP4; NbExp=3; IntAct=EBI-7545592, EBI-744953;
CC Q9H6H4; O95183: VAMP5; NbExp=3; IntAct=EBI-7545592, EBI-10191195;
CC Q9H6H4; O95292: VAPB; NbExp=3; IntAct=EBI-7545592, EBI-1188298;
CC Q9H6H4; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-7545592, EBI-723716;
CC Q9H6H4; O95070: YIF1A; NbExp=3; IntAct=EBI-7545592, EBI-2799703;
CC Q9H6H4; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-7545592, EBI-751253;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:23911198}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:23911198}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H6H4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6H4-2; Sequence=VSP_016636, VSP_016637;
CC -!- TISSUE SPECIFICITY: Expressed in circumvallate papillae and testis.
CC {ECO:0000269|PubMed:16720576}.
CC -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR EMBL; AY562242; AAT70687.1; -; mRNA.
DR EMBL; AK025899; BAB15274.1; -; mRNA.
DR EMBL; AK025930; BAB15285.1; -; mRNA.
DR EMBL; AK172846; BAD18810.1; -; mRNA.
DR EMBL; AF218014; AAG17256.1; -; mRNA.
DR EMBL; CR457353; CAG33634.1; -; mRNA.
DR EMBL; AC105206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471080; EAW63710.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63715.1; -; Genomic_DNA.
DR EMBL; BC013048; AAH13048.1; -; mRNA.
DR EMBL; BC050622; AAH50622.1; -; mRNA.
DR CCDS; CCDS6024.1; -. [Q9H6H4-1]
DR CCDS; CCDS83257.1; -. [Q9H6H4-2]
DR RefSeq; NP_001303893.1; NM_001316964.1.
DR RefSeq; NP_001303894.1; NM_001316965.1. [Q9H6H4-2]
DR RefSeq; NP_079508.2; NM_025232.3. [Q9H6H4-1]
DR AlphaFoldDB; Q9H6H4; -.
DR BioGRID; 123253; 189.
DR IntAct; Q9H6H4; 126.
DR MINT; Q9H6H4; -.
DR STRING; 9606.ENSP00000303482; -.
DR iPTMnet; Q9H6H4; -.
DR PhosphoSitePlus; Q9H6H4; -.
DR SwissPalm; Q9H6H4; -.
DR BioMuta; REEP4; -.
DR DMDM; 74733607; -.
DR EPD; Q9H6H4; -.
DR jPOST; Q9H6H4; -.
DR MassIVE; Q9H6H4; -.
DR MaxQB; Q9H6H4; -.
DR PaxDb; Q9H6H4; -.
DR PeptideAtlas; Q9H6H4; -.
DR PRIDE; Q9H6H4; -.
DR ProteomicsDB; 80986; -. [Q9H6H4-1]
DR ProteomicsDB; 80987; -. [Q9H6H4-2]
DR Antibodypedia; 22523; 143 antibodies from 23 providers.
DR DNASU; 80346; -.
DR Ensembl; ENST00000306306.8; ENSP00000303482.3; ENSG00000168476.12. [Q9H6H4-1]
DR Ensembl; ENST00000334530.9; ENSP00000333889.5; ENSG00000168476.12. [Q9H6H4-2]
DR GeneID; 80346; -.
DR KEGG; hsa:80346; -.
DR MANE-Select; ENST00000306306.8; ENSP00000303482.3; NM_025232.4; NP_079508.2.
DR UCSC; uc003xau.2; human. [Q9H6H4-1]
DR CTD; 80346; -.
DR DisGeNET; 80346; -.
DR GeneCards; REEP4; -.
DR HGNC; HGNC:26176; REEP4.
DR HPA; ENSG00000168476; Tissue enhanced (esophagus, skin).
DR MIM; 609349; gene.
DR neXtProt; NX_Q9H6H4; -.
DR OpenTargets; ENSG00000168476; -.
DR PharmGKB; PA134890554; -.
DR VEuPathDB; HostDB:ENSG00000168476; -.
DR eggNOG; KOG1726; Eukaryota.
DR GeneTree; ENSGT00940000161674; -.
DR HOGENOM; CLU_028431_4_1_1; -.
DR InParanoid; Q9H6H4; -.
DR OrthoDB; 1473891at2759; -.
DR PhylomeDB; Q9H6H4; -.
DR TreeFam; TF314177; -.
DR PathwayCommons; Q9H6H4; -.
DR SignaLink; Q9H6H4; -.
DR BioGRID-ORCS; 80346; 19 hits in 1074 CRISPR screens.
DR ChiTaRS; REEP4; human.
DR GenomeRNAi; 80346; -.
DR Pharos; Q9H6H4; Tbio.
DR PRO; PR:Q9H6H4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9H6H4; protein.
DR Bgee; ENSG00000168476; Expressed in lower esophagus mucosa and 135 other tissues.
DR ExpressionAtlas; Q9H6H4; baseline and differential.
DR Genevisible; Q9H6H4; HS.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; IMP:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; IMP:UniProtKB.
DR InterPro; IPR004345; TB2_DP1_HVA22.
DR PANTHER; PTHR12300; PTHR12300; 1.
DR Pfam; PF03134; TB2_DP1_HVA22; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Endoplasmic reticulum;
KW Membrane; Microtubule; Mitosis; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..257
FT /note="Receptor expression-enhancing protein 4"
FT /id="PRO_0000101830"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 183..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 196
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 250
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 140..173
FT /note="SQGALAGRLRSFSMQDLRSISDAPAPAYHDPLYL -> GTGPGACRTATPRM
FT SVGQILRQSPGRQPGPERSP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016636"
FT VAR_SEQ 174..257
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016637"
FT CONFLICT 149
FT /note="R -> Q (in Ref. 3; AAG17256)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="S -> P (in Ref. 2; BAB15274)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 257 AA; 29395 MW; EA7AB1B9EDB3DB1A CRC64;
MVSWMICRLV VLVFGMLCPA YASYKAVKTK NIREYVRWMM YWIVFALFMA AEIVTDIFIS
WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDAYIVQA KERSYETVLS
FGKRGLNIAA SAAVQAATKS QGALAGRLRS FSMQDLRSIS DAPAPAYHDP LYLEDQVSHR
RPPIGYRAGG LQDSDTEDEC WSDTEAVPRA PARPREKPLI RSQSLRVVKR KPPVREGTSR
SLKVRTRKKT VPSDVDS
