REEP4_MOUSE
ID REEP4_MOUSE Reviewed; 257 AA.
AC Q8K072;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Receptor expression-enhancing protein 4;
GN Name=Reep4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; THR-196 AND SER-202, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC division and nuclear envelope reassembly by sequestering the
CC endoplasmic reticulum away from chromosomes during mitosis. Probably
CC acts by clearing the endoplasmic reticulum membrane from metaphase
CC chromosomes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR EMBL; AY562232; AAT70677.1; -; mRNA.
DR EMBL; BC033929; AAH33929.1; -; mRNA.
DR CCDS; CCDS27256.1; -.
DR RefSeq; NP_850919.1; NM_180588.2.
DR AlphaFoldDB; Q8K072; -.
DR STRING; 10090.ENSMUSP00000040162; -.
DR iPTMnet; Q8K072; -.
DR PhosphoSitePlus; Q8K072; -.
DR EPD; Q8K072; -.
DR jPOST; Q8K072; -.
DR MaxQB; Q8K072; -.
DR PaxDb; Q8K072; -.
DR PeptideAtlas; Q8K072; -.
DR PRIDE; Q8K072; -.
DR ProteomicsDB; 255008; -.
DR Antibodypedia; 22523; 143 antibodies from 23 providers.
DR DNASU; 72549; -.
DR Ensembl; ENSMUST00000047218; ENSMUSP00000040162; ENSMUSG00000033589.
DR GeneID; 72549; -.
DR KEGG; mmu:72549; -.
DR UCSC; uc007uoi.2; mouse.
DR CTD; 80346; -.
DR MGI; MGI:1919799; Reep4.
DR VEuPathDB; HostDB:ENSMUSG00000033589; -.
DR eggNOG; KOG1726; Eukaryota.
DR GeneTree; ENSGT00940000161674; -.
DR HOGENOM; CLU_028431_0_1_1; -.
DR InParanoid; Q8K072; -.
DR PhylomeDB; Q8K072; -.
DR TreeFam; TF314177; -.
DR BioGRID-ORCS; 72549; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Reep4; mouse.
DR PRO; PR:Q8K072; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8K072; protein.
DR Bgee; ENSMUSG00000033589; Expressed in lip and 155 other tissues.
DR ExpressionAtlas; Q8K072; baseline and differential.
DR Genevisible; Q8K072; MM.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; ISS:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR InterPro; IPR004345; TB2_DP1_HVA22.
DR PANTHER; PTHR12300; PTHR12300; 1.
DR Pfam; PF03134; TB2_DP1_HVA22; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Endoplasmic reticulum; Membrane; Microtubule;
KW Mitosis; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..257
FT /note="Receptor expression-enhancing protein 4"
FT /id="PRO_0000101831"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 177..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 196
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H6H4"
SQ SEQUENCE 257 AA; 29691 MW; 69C3877CC439EF28 CRC64;
MVSWMICRLV VLIFGMLYPA YASYKAVKSK NIREYVRWMM YWIVFAIFMA AETFTDIFIS
WFPFYYEFKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDACIVQA KERSYETMLS
FGKRSLNIAA SAAVQAATKS QGALAGRLRS FSMQDLRSIP DTPVPTYQDP LYLEDQVPRR
RPPIGYRPGG LQGSDTEDEC WSDNEIVPQP PVRPREKPLG RSQSLRVVKR KPLTREGTSR
SLKVRTRKKA MPSDMDS
