REEP4_XENTR
ID REEP4_XENTR Reviewed; 261 AA.
AC Q5BL63; F7CB07;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Receptor expression-enhancing protein 4;
GN Name=reep4; ORFNames=TEgg068f10.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=19123125; DOI=10.1387/ijdb.072542ja;
RA Argasinska J., Rana A.A., Gilchrist M.J., Lachani K., Young A., Smith J.C.;
RT "Loss of REEP4 causes paralysis of the Xenopus embryo.";
RL Int. J. Dev. Biol. 53:37-43(2009).
CC -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC division and nuclear envelope reassembly by sequestering the
CC endoplasmic reticulum away from chromosomes during mitosis. Probably
CC acts by clearing the endoplasmic reticulum membrane from metaphase
CC chromosomes (By similarity). May play a role in the maintenance of both
CC the nervous system and the musculature. {ECO:0000250,
CC ECO:0000269|PubMed:19123125}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: During gastrulation, expressed on the dorsal side
CC of the embryo and then in the neural plate and neural tube. At tailbud
CC stages, expressed in the somites. Expressed in the neural tube later in
CC development.
CC -!- MISCELLANEOUS: Inactivation in embryos by antisense morpholino causes
CC paralysis and shortening of the body axis.
CC {ECO:0000305|PubMed:19123125}.
CC -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR EMBL; CR926301; CAJ83633.1; -; mRNA.
DR EMBL; AAMC01015449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC090588; AAH90588.1; -; mRNA.
DR RefSeq; NP_001016224.1; NM_001016224.2.
DR AlphaFoldDB; Q5BL63; -.
DR STRING; 8364.ENSXETP00000023109; -.
DR PaxDb; Q5BL63; -.
DR DNASU; 548978; -.
DR Ensembl; ENSXETT00000085355; ENSXETP00000076288; ENSXETG00000010537.
DR GeneID; 548978; -.
DR KEGG; xtr:548978; -.
DR CTD; 80346; -.
DR Xenbase; XB-GENE-982259; reep4.
DR eggNOG; KOG1726; Eukaryota.
DR OrthoDB; 1473891at2759; -.
DR TreeFam; TF314177; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000010537; Expressed in 2-cell stage embryo and 19 other tissues.
DR ExpressionAtlas; Q5BL63; baseline.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0071782; C:endoplasmic reticulum tubular network; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; ISS:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR InterPro; IPR004345; TB2_DP1_HVA22.
DR PANTHER; PTHR12300; PTHR12300; 1.
DR Pfam; PF03134; TB2_DP1_HVA22; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Endoplasmic reticulum; Membrane; Microtubule;
KW Mitosis; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..261
FT /note="Receptor expression-enhancing protein 4"
FT /id="PRO_0000424024"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 177..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 29826 MW; A8DDAA72E0742E08 CRC64;
MVSWIISRAV VLVFGLLYPA YASYKAVKTK NVREYVRWMM YWIVFALFMT VETFTDIFIA
WFPFYYEIKM AFVVWLLSPY TRGASLLYRK CIHPTLSLKE KEIDSYIIQA KERSYESFVN
IGRKGLNIAA SAAVQAATKG QGALVGRLRS FSMQDLRALP DDTPIHYRDA LYPDAPELHR
RPIGYPTTSH ADSDSMDERW SDSEMAETRT AARTRGGMPS KPLQRSQSLR VSKKKGLSRE
VSTKTTKPKG KKKPAQSEPE N
