ID   REEP6_BOVIN             Reviewed;         185 AA.
AC   Q32LG5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Receptor expression-enhancing protein 6;
GN   Name=REEP6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH CLATHRIN, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=28369466; DOI=10.1093/hmg/ddx111;
RA   Veleri S., Nellissery J., Mishra B., Manjunath S.H., Brooks M.J., Dong L.,
RA   Nagashima K., Qian H., Gao C., Sergeev Y.V., Huang X.F., Qu J., Lu F.,
RA   Cideciyan A.V., Li T., Jin Z.B., Fariss R.N., Ratnapriya R., Jacobson S.G.,
RA   Swaroop A.;
RT   "REEP6 mediates trafficking of a subset of Clathrin-coated vesicles and is
RT   critical for rod photoreceptor function and survival.";
RL   Hum. Mol. Genet. 26:2218-2230(2017).
CC   -!- FUNCTION: Required for correct function and survival of retinal
CC       photoreceptors (By similarity). Required for retinal development (By
CC       similarity). In rod photoreceptors, facilitates stability and/or
CC       trafficking of guanylate cyclases and is required to maintain
CC       endoplasmic reticulum and mitochondrial homeostasis (By similarity).
CC       May play a role in clathrin-coated intracellular vesicle trafficking of
CC       proteins from the endoplasmic reticulum to the retinal rod plasma
CC       membrane (By similarity). {ECO:0000250|UniProtKB:Q9JM62}.
CC   -!- SUBUNIT: Interacts with STX3 (By similarity). Interacts with clathrin
CC       (PubMed:28369466). {ECO:0000250|UniProtKB:Q9JM62,
CC       ECO:0000269|PubMed:28369466}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9JM62}; Multi-pass membrane protein
CC       {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane
CC       {ECO:0000269|PubMed:28369466}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in the retina (at protein level).
CC       {ECO:0000269|PubMed:28369466}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC109592; AAI09593.1; -; mRNA.
DR   RefSeq; NP_001033224.1; NM_001038135.2.
DR   AlphaFoldDB; Q32LG5; -.
DR   SMR; Q32LG5; -.
DR   STRING; 9913.ENSBTAP00000002978; -.
DR   PaxDb; Q32LG5; -.
DR   PeptideAtlas; Q32LG5; -.
DR   Ensembl; ENSBTAT00000002978; ENSBTAP00000002978; ENSBTAG00000002311.
DR   GeneID; 522480; -.
DR   KEGG; bta:522480; -.
DR   CTD; 92840; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002311; -.
DR   VGNC; VGNC:33856; REEP6.
DR   eggNOG; KOG1725; Eukaryota.
DR   GeneTree; ENSGT00940000161493; -.
DR   HOGENOM; CLU_028431_2_0_1; -.
DR   InParanoid; Q32LG5; -.
DR   OMA; WIPFYFF; -.
DR   OrthoDB; 1473891at2759; -.
DR   TreeFam; TF314913; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000002311; Expressed in retina and 103 other tissues.
DR   GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; ISS:UniProtKB.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..185
FT                   /note="Receptor expression-enhancing protein 6"
FT                   /id="PRO_0000244385"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   185 AA;  20574 MW;  E95D13EB1655D577 CRC64;
     MDGLRQRFER FLEQRNLATE ALGALEAKTG VDKRYLATGA ATLLSLYLLF GYGAPLLCSL
     IGFAYPAYAS IKAIESPSKE DDTVWLTYWV VYGLFGLAEF FSDLLLSWFP FYYAGKCAFL
     LFCMAPGPWN GAHMLYHRII RPLFLKHHEA VDSIVSDISG RALDVAAGMT KDAGKVSVNQ
     LQKAK