ID   REEP6_RAT               Reviewed;         211 AA.
AC   Q5XI60;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Receptor expression-enhancing protein 6;
DE   AltName: Full=Polyposis locus protein 1-like 1;
GN   Name=Reep6; Synonyms=Dp1l1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=15728532; DOI=10.1167/iovs.04-0867;
RA   Sato H., Tomita H., Nakazawa T., Wakana S., Tamai M.;
RT   "Deleted in polyposis 1-like 1 gene (Dp1l1): a novel gene richly expressed
RT   in retinal ganglion cells.";
RL   Invest. Ophthalmol. Vis. Sci. 46:791-796(2005).
CC   -!- FUNCTION: Required for correct function and survival of retinal
CC       photoreceptors (By similarity). Required for retinal development (By
CC       similarity). In rod photoreceptors, facilitates stability and/or
CC       trafficking of guanylate cyclases and is required to maintain
CC       endoplasmic reticulum and mitochondrial homeostasis (By similarity).
CC       May play a role in clathrin-coated intracellular vesicle trafficking of
CC       proteins from the endoplasmic reticulum to the retinal rod plasma
CC       membrane (By similarity). {ECO:0000250|UniProtKB:Q9JM62}.
CC   -!- SUBUNIT: Interacts with STX3 (By similarity). Interacts with clathrin
CC       (By similarity). {ECO:0000250|UniProtKB:Q9JM62}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9JM62}; Multi-pass membrane protein
CC       {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane
CC       {ECO:0000250|UniProtKB:Q9JM62}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Detected in retina. {ECO:0000269|PubMed:15728532}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC083830; AAH83830.1; -; mRNA.
DR   RefSeq; NP_001013236.1; NM_001013218.1.
DR   AlphaFoldDB; Q5XI60; -.
DR   SMR; Q5XI60; -.
DR   IntAct; Q5XI60; 8.
DR   STRING; 10116.ENSRNOP00000039493; -.
DR   iPTMnet; Q5XI60; -.
DR   PhosphoSitePlus; Q5XI60; -.
DR   jPOST; Q5XI60; -.
DR   PaxDb; Q5XI60; -.
DR   PRIDE; Q5XI60; -.
DR   Ensembl; ENSRNOT00000044030; ENSRNOP00000039493; ENSRNOG00000033262.
DR   GeneID; 362835; -.
DR   KEGG; rno:362835; -.
DR   UCSC; RGD:1309508; rat.
DR   CTD; 92840; -.
DR   RGD; 1309508; Reep6.
DR   eggNOG; KOG1725; Eukaryota.
DR   GeneTree; ENSGT00940000161493; -.
DR   HOGENOM; CLU_028431_2_0_1; -.
DR   InParanoid; Q5XI60; -.
DR   OMA; HQATMDS; -.
DR   OrthoDB; 1473891at2759; -.
DR   PhylomeDB; Q5XI60; -.
DR   TreeFam; TF314913; -.
DR   PRO; PR:Q5XI60; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000033262; Expressed in testis and 19 other tissues.
DR   Genevisible; Q5XI60; RN.
DR   GO; GO:0045177; C:apical part of cell; ISO:RGD.
DR   GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR   GO; GO:0044317; C:rod spherule; ISO:RGD.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; ISS:UniProtKB.
DR   GO; GO:0032386; P:regulation of intracellular transport; ISO:RGD.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..211
FT                   /note="Receptor expression-enhancing protein 6"
FT                   /id="PRO_0000101820"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          188..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   211 AA;  23313 MW;  D51FFD3C617C59B6 CRC64;
     MDGLRQRFER FLEQKNVATD ALGALEARTG VEKRYLAAGA LTLLGLYLLF GYGASLLCNV
     IGFVYPAYAS VKAIESPNKE DDTVWLTYWV VYALFGLVEF FSDLLLFWFP FYYAGKCAFL
     LFCMTPGPWN GALLLYHRVI RPLFLKHHVA LDSAASQLSG RALDIAAGIT RDVLQALARG
     RTLVTPASAS ESPAALEPDP KSSQTTLLKH K