REG1B_HUMAN
ID REG1B_HUMAN Reviewed; 166 AA.
AC P48304;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Lithostathine-1-beta;
DE AltName: Full=Pancreatic stone protein 2;
DE Short=PSP-2;
DE AltName: Full=Regenerating islet-derived protein 1-beta;
DE Short=REG-1-beta;
DE AltName: Full=Regenerating protein I beta;
DE Flags: Precursor;
GN Name=REG1B; Synonyms=PSPS2, REGL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8348956; DOI=10.1016/0014-5793(93)81006-l;
RA Bartoli C., Gharib B., Giorgi D., Sansonetti A., Dagorn J.-C.,
RA Berge-Lefranc U.;
RT "A gene homologous to the reg gene is expressed in the human pancreas.";
RL FEBS Lett. 327:289-293(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Pancreas;
RX PubMed=8110835; DOI=10.1016/0167-4781(94)90035-3;
RA Moriizumi S., Watanabe T., Unno M., Nakagawara K., Suzuki Y., Miyashita H.,
RA Yonekura H., Okamoto H.;
RT "Isolation, structural determination and expression of a novel reg gene,
RT human regI beta.";
RL Biochim. Biophys. Acta 1217:199-202(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GLYCOSYLATION AT THR-27.
RX PubMed=7607222; DOI=10.1111/j.1432-1033.1995.tb20589.x;
RA De Reggi M., Capon C., Gharib B., Wieruszeski J.-M., Michel R., Fournet B.;
RT "The glycan moiety of human pancreatic lithostathine. Structure
RT characterization and possible pathophysiological implications.";
RL Eur. J. Biochem. 230:503-510(1995).
CC -!- FUNCTION: Might act as an inhibitor of spontaneous calcium carbonate
CC precipitation. May be associated with neuronal sprouting in brain, and
CC with brain and pancreas regeneration.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc
CC tetrasaccharide core and get elongated (microheterogeneity).
CC {ECO:0000269|PubMed:7607222}.
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=Lithostathine A;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_255";
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DR EMBL; L08010; AAA18204.1; -; Genomic_DNA.
DR EMBL; D17291; BAA04124.1; -; Genomic_DNA.
DR EMBL; D16816; BAA04091.1; -; mRNA.
DR EMBL; BC027895; AAH27895.1; -; mRNA.
DR CCDS; CCDS1963.1; -.
DR PIR; S34591; RGHU1B.
DR RefSeq; NP_006498.1; NM_006507.3.
DR AlphaFoldDB; P48304; -.
DR SMR; P48304; -.
DR BioGRID; 111900; 6.
DR IntAct; P48304; 3.
DR MINT; P48304; -.
DR STRING; 9606.ENSP00000303206; -.
DR MEROPS; I63.002; -.
DR GlyGen; P48304; 1 site.
DR iPTMnet; P48304; -.
DR PhosphoSitePlus; P48304; -.
DR BioMuta; REG1B; -.
DR DMDM; 1346460; -.
DR jPOST; P48304; -.
DR MassIVE; P48304; -.
DR PaxDb; P48304; -.
DR PeptideAtlas; P48304; -.
DR PRIDE; P48304; -.
DR ProteomicsDB; 55874; -.
DR Antibodypedia; 47486; 182 antibodies from 22 providers.
DR DNASU; 5968; -.
DR Ensembl; ENST00000305089.8; ENSP00000303206.3; ENSG00000172023.8.
DR GeneID; 5968; -.
DR KEGG; hsa:5968; -.
DR MANE-Select; ENST00000305089.8; ENSP00000303206.3; NM_006507.4; NP_006498.1.
DR CTD; 5968; -.
DR DisGeNET; 5968; -.
DR GeneCards; REG1B; -.
DR HGNC; HGNC:9952; REG1B.
DR HPA; ENSG00000172023; Tissue enriched (pancreas).
DR MIM; 167771; gene.
DR neXtProt; NX_P48304; -.
DR OpenTargets; ENSG00000172023; -.
DR PharmGKB; PA34319; -.
DR VEuPathDB; HostDB:ENSG00000172023; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000163728; -.
DR HOGENOM; CLU_049894_18_0_1; -.
DR InParanoid; P48304; -.
DR OMA; QTNSFFM; -.
DR OrthoDB; 1509611at2759; -.
DR PhylomeDB; P48304; -.
DR PathwayCommons; P48304; -.
DR SignaLink; P48304; -.
DR BioGRID-ORCS; 5968; 8 hits in 1022 CRISPR screens.
DR ChiTaRS; REG1B; human.
DR GeneWiki; REG1B; -.
DR GenomeRNAi; 5968; -.
DR Pharos; P48304; Tbio.
DR PRO; PR:P48304; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P48304; protein.
DR Bgee; ENSG00000172023; Expressed in body of pancreas and 87 other tissues.
DR ExpressionAtlas; P48304; baseline and differential.
DR Genevisible; P48304; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0070492; F:oligosaccharide binding; IBA:GO_Central.
DR GO; GO:0042834; F:peptidoglycan binding; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0044278; P:cell wall disruption in another organism; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0043434; P:response to peptide hormone; IBA:GO_Central.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..166
FT /note="Lithostathine-1-beta"
FT /id="PRO_0000017425"
FT DOMAIN 34..164
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 27
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:7607222"
FT DISULFID 36..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 64..162
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 137..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VARIANT 109
FT /note="R -> H (in dbSNP:rs7586984)"
FT /id="VAR_050121"
SQ SEQUENCE 166 AA; 18665 MW; D1DC20E11AE5DDE8 CRC64;
MAQTNSFFML ISSLMFLSLS QGQESQTELP NPRISCPEGT NAYRSYCYYF NEDPETWVDA
DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI GLHDPKKNRR WHWSSGSLVS
YKSWDTGSPS SANAGYCASL TSCSGFKKWK DESCEKKFSF VCKFKN
