ID   REG1_BOVIN              Reviewed;          92 AA.
AC   P82943; Q8MI76;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Regakine-1;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11570872; DOI=10.1021/bi010224+;
RA   Struyf S., Stoops G., Van Coillie E., Gouwy M., Schutyser E.,
RA   Lenaerts J.-P., Fiten P., Van Aelst I., Proost P., Opdenakker G.,
RA   Van Damme J.;
RT   "Gene cloning of a new plasma CC chemokine, activating and attracting
RT   myeloid cells in synergy with other chemoattractants.";
RL   Biochemistry 40:11715-11722(2001).
RN   [2]
RP   PROTEIN SEQUENCE OF 22-91, FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Serum;
RX   PubMed=11290579; DOI=10.1182/blood.v97.8.2197;
RA   Struyf S., Proost P., Lenaerts J.-P., Stoops S., Wuyts A., Van Damme J.;
RT   "Identification of a blood-derived chemoattractant for neutrophils and
RT   lymphocytes as a novel CC chemokine, Regakine-1.";
RL   Blood 97:2197-2204(2001).
CC   -!- FUNCTION: Chemotactic activity for neutrophils and lymphocytes. Binds
CC       to heparin. {ECO:0000269|PubMed:11290579}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Plasma serum. {ECO:0000269|PubMed:11290579}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ313203; CAC85743.1; -; Genomic_DNA.
DR   RefSeq; NP_001029392.1; NM_001034220.2.
DR   AlphaFoldDB; P82943; -.
DR   SMR; P82943; -.
DR   STRING; 9913.ENSBTAP00000013399; -.
DR   PaxDb; P82943; -.
DR   PRIDE; P82943; -.
DR   Ensembl; ENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
DR   GeneID; 504773; -.
DR   KEGG; bta:504773; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010155; -.
DR   eggNOG; ENOG502TCP9; Eukaryota.
DR   GeneTree; ENSGT01050000244851; -.
DR   HOGENOM; CLU_141716_4_2_1; -.
DR   InParanoid; P82943; -.
DR   OMA; ICANPGQ; -.
DR   OrthoDB; 1575018at2759; -.
DR   TreeFam; TF334888; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000010155; Expressed in lung and 103 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Heparin-binding; Inflammatory response; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:11290579"
FT   CHAIN           22..92
FT                   /note="Regakine-1"
FT                   /id="PRO_0000005140"
FT   DISULFID        32..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..72
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10281 MW;  797B53A5C0CA334A CRC64;
     MRVSLAALAF LLTLAVLHSE ANEEPAGNMR VCCFSSVTRK IPLSLVKNYE RTGDKCPQEA
     VIFQTRSGRS ICANPGQAWV QKYIEYLDQM SK