ID   REG1_STRLI              Reviewed;         345 AA.
AC   P72469;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HTH-type transcriptional regulator reg1;
GN   Name=reg1;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TK24;
RX   PubMed=9335287; DOI=10.1128/jb.179.20.6383-6390.1997;
RA   Nguyen J., Francou F., Virolle M.J., Guerineau M.;
RT   "Amylase and chitinase genes in Streptomyces lividans are regulated by
RT   reg1, a pleiotropic regulatory gene.";
RL   J. Bacteriol. 179:6383-6390(1997).
CC   -!- FUNCTION: Transcription repressor involved in control of expression of
CC       alpha-amylase and chitinase genes and of actinorhodin production.
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DR   EMBL; X98242; CAA66898.1; -; Genomic_DNA.
DR   AlphaFoldDB; P72469; -.
DR   SMR; P72469; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..345
FT                   /note="HTH-type transcriptional regulator reg1"
FT                   /id="PRO_0000107995"
FT   DOMAIN          1..58
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   345 AA;  36424 MW;  06E2BD300C9BB4F7 CRC64;
     MTTRLADIAA QAGVSEATVS RVLNGKPGVA ATTRQSVLAA LDVLGYERPV RLRRRSAGLV
     GLVTPELENP IFPAFAQVIG QALTRQGYTP VLATQTPGGS TEDELTEMLV DRGVAGIIYV
     SGLHADTTAD MQRYERLGGR GVPFVLVDGF SSQVQAPFIS PDDRAAMSLA VTHLVSLGHT
     RIGLALGPKR FVPVQRKIEG FVRTVQEPVG AERRSTVEKE LVQHSLYTLE GGQAAASALI
     GRDCTAVVCA SDMMALGAIR AARQLGLDVP KDVSVVGFDD SPLIAFTDPP LTTVRKPVPA
     MGQAAVRTLL EEIGGTPAPH SEFVFMPELV VRGSTASAPG ERGRP