ID   REG2_DROME              Reviewed;         260 AA.
AC   Q94915; Q9W0P6;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Rhythmically expressed gene 2 protein;
DE   AltName: Full=dREG-2;
GN   Name=Reg-2; ORFNames=CG3200;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Canton-S;
RX   PubMed=8749395; DOI=10.1016/s0960-9822(95)00280-6;
RA   van Gelder R.N., Bae H., Palazzolo M.J., Krasnow M.A.;
RT   "Extent and character of circadian gene expression in Drosophila
RT   melanogaster: identification of twenty oscillating mRNAs in the fly head.";
RL   Curr. Biol. 5:1424-1436(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- INDUCTION: Maximally expressed at predawn or early morning.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U65492; AAC47289.1; -; mRNA.
DR   EMBL; AE014296; AAF47397.1; -; Genomic_DNA.
DR   RefSeq; NP_612043.1; NM_138199.3.
DR   AlphaFoldDB; Q94915; -.
DR   SMR; Q94915; -.
DR   BioGRID; 63630; 1.
DR   STRING; 7227.FBpp0072460; -.
DR   PaxDb; Q94915; -.
DR   PRIDE; Q94915; -.
DR   DNASU; 38075; -.
DR   EnsemblMetazoa; FBtr0072561; FBpp0072460; FBgn0016715.
DR   GeneID; 38075; -.
DR   KEGG; dme:Dmel_CG3200; -.
DR   CTD; 38075; -.
DR   FlyBase; FBgn0016715; Reg-2.
DR   VEuPathDB; VectorBase:FBgn0016715; -.
DR   eggNOG; KOG3085; Eukaryota.
DR   GeneTree; ENSGT00940000168936; -.
DR   HOGENOM; CLU_045011_8_0_1; -.
DR   InParanoid; Q94915; -.
DR   OMA; WWRQLIA; -.
DR   OrthoDB; 1119971at2759; -.
DR   PhylomeDB; Q94915; -.
DR   BioGRID-ORCS; 38075; 1 hit in 3 CRISPR screens.
DR   GenomeRNAi; 38075; -.
DR   PRO; PR:Q94915; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0016715; Expressed in arthropod fat body and 34 other tissues.
DR   ExpressionAtlas; Q94915; baseline and differential.
DR   Genevisible; Q94915; DM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   Gene3D; 1.10.150.720; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR011949; HAD-SF_hydro_IA_REG-2-like.
DR   InterPro; IPR044924; HAD-SF_hydro_IA_REG-2-like_cap.
DR   InterPro; IPR041492; HAD_2.
DR   InterPro; IPR023214; HAD_sf.
DR   Pfam; PF13419; HAD_2; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR02252; DREG-2; 1.
DR   TIGRFAMs; TIGR01549; HAD-SF-IA-v1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..260
FT                   /note="Rhythmically expressed gene 2 protein"
FT                   /id="PRO_0000097240"
SQ   SEQUENCE   260 AA;  30113 MW;  5E074BB38B5668EE CRC64;
     MRSLSRFRLI TFDVTNTLLQ FRTTPGKQYG EIGALFGARC DNNELAKNFK ANWYKMNRDY
     PNFGRDTNPQ MEWQQWWRKL IAGTFAESGA AIPDEKLHNF SNHLIELYKT SICWQPCNGS
     VELLQQLRKE LKPEKCKLGV IANFDPRLPT LLQNTKLDQY LDFAINSYEV QAEKPDPQIF
     QKAMEKSGLK NLKPEECLHI GDGPTTDYLA AKELGWHSAL VHEKSYAYLV KKYGEDIDRD
     HVFPSLYDFH KKISDGAVVW