REG2_PYRHO
ID REG2_PYRHO Reviewed; 148 AA.
AC O57802;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Uncharacterized HTH-type transcriptional regulator PH0061;
GN OrderedLocusNames=PH0061;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RG RIKEN structural genomics initiative (RSGI);
RT "Crystal structure of PH0061.";
RL Submitted (JUN-2006) to the PDB data bank.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA29129.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000001; BAA29129.1; ALT_INIT; Genomic_DNA.
DR PIR; B71225; B71225.
DR RefSeq; WP_048053019.1; NC_000961.1.
DR PDB; 2DBB; X-ray; 2.00 A; A/B=1-148.
DR PDBsum; 2DBB; -.
DR AlphaFoldDB; O57802; -.
DR SMR; O57802; -.
DR STRING; 70601.3256446; -.
DR EnsemblBacteria; BAA29129; BAA29129; BAA29129.
DR GeneID; 1443959; -.
DR KEGG; pho:PH0061; -.
DR eggNOG; arCOG01581; Archaea.
DR OMA; HIVGPKD; -.
DR OrthoDB; 97695at2157; -.
DR EvolutionaryTrace; O57802; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54909; SSF54909; 1.
DR PROSITE; PS00519; HTH_ASNC_1; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..148
FT /note="Uncharacterized HTH-type transcriptional regulator
FT PH0061"
FT /id="PRO_0000111759"
FT DOMAIN 4..65
FT /note="HTH asnC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT DNA_BIND 23..42
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT HELIX 6..17
FT /evidence="ECO:0007829|PDB:2DBB"
FT HELIX 23..29
FT /evidence="ECO:0007829|PDB:2DBB"
FT HELIX 34..46
FT /evidence="ECO:0007829|PDB:2DBB"
FT STRAND 49..57
FT /evidence="ECO:0007829|PDB:2DBB"
FT HELIX 60..62
FT /evidence="ECO:0007829|PDB:2DBB"
FT STRAND 64..75
FT /evidence="ECO:0007829|PDB:2DBB"
FT HELIX 76..86
FT /evidence="ECO:0007829|PDB:2DBB"
FT STRAND 92..101
FT /evidence="ECO:0007829|PDB:2DBB"
FT STRAND 103..113
FT /evidence="ECO:0007829|PDB:2DBB"
FT HELIX 114..126
FT /evidence="ECO:0007829|PDB:2DBB"
FT STRAND 130..145
FT /evidence="ECO:0007829|PDB:2DBB"
SQ SEQUENCE 148 AA; 17242 MW; 5FAC4E12710A21DA CRC64;
MRKLDRVDMQ LVKILSENSR LTYRELADIL NTTRQRIARR IDKLKKLGII RKFTIIPDID
KLGYMYAIVL IKSKVPSDAD KVISEISDIE YVKSVEKGVG RYNIIVRLLL PKDIKDAENL
ISEFLQRIKN AENVEVILIS EVRKFEII
