REG2_YEAST
ID REG2_YEAST Reviewed; 338 AA.
AC P38232; D6VQ50;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein REG2;
GN Name=REG2; OrderedLocusNames=YBR050C; ORFNames=YBR0504;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7597852; DOI=10.1002/yea.320110511;
RA Aljinovic G., Pohl T.M.;
RT "Sequence and analysis of 24 kb on chromosome II of Saccharomyces
RT cerevisiae.";
RL Yeast 11:475-479(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION.
RX PubMed=8649403; DOI=10.1128/mcb.16.6.2922;
RA Frederick D.L., Tatchell K.;
RT "The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein
RT phosphatase-binding protein that functions with Reg1p and the Snf1 protein
RT kinase to regulate growth.";
RL Mol. Cell. Biol. 16:2922-2931(1996).
CC -!- FUNCTION: Regulatory subunit, binds to type-1 protein phosphatase.
CC Functions with HEX2/REG1 and SNF1 protein kinase to regulate growth.
CC Might regulate SNF1 directly or indirectly.
CC {ECO:0000269|PubMed:8649403}.
CC -!- INTERACTION:
CC P38232; P06782: SNF1; NbExp=3; IntAct=EBI-14921, EBI-17516;
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DR EMBL; Z35919; CAA84994.1; -; Genomic_DNA.
DR EMBL; Z46260; CAA86393.1; -; Genomic_DNA.
DR EMBL; AY557867; AAS56193.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07170.1; -; Genomic_DNA.
DR PIR; S45908; S45908.
DR RefSeq; NP_009606.1; NM_001178398.1.
DR AlphaFoldDB; P38232; -.
DR BioGRID; 32752; 43.
DR ComplexPortal; CPX-1267; REG2-GLC7 phosphatase complex.
DR DIP; DIP-2377N; -.
DR IntAct; P38232; 3.
DR MINT; P38232; -.
DR STRING; 4932.YBR050C; -.
DR PaxDb; P38232; -.
DR PRIDE; P38232; -.
DR EnsemblFungi; YBR050C_mRNA; YBR050C; YBR050C.
DR GeneID; 852340; -.
DR KEGG; sce:YBR050C; -.
DR SGD; S000000254; REG2.
DR VEuPathDB; FungiDB:YBR050C; -.
DR HOGENOM; CLU_816848_0_0_1; -.
DR OMA; RHIKFND; -.
DR BioCyc; YEAST:G3O-29022-MON; -.
DR PRO; PR:P38232; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38232; protein.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IPI:SGD.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IDA:SGD.
DR GO; GO:1904547; P:regulation of cellular response to glucose starvation; IC:ComplexPortal.
DR GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IMP:SGD.
DR InterPro; IPR013860; AreA_GATA.
DR Pfam; PF08550; DUF1752; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..338
FT /note="Protein REG2"
FT /id="PRO_0000071523"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 38747 MW; 60A26FDE19ED36F7 CRC64;
MTLSNCDSLD NLFQDPPEEE ESSKFVEAVR TLMNRNDMGY PPAAANGTYC LKKIKSLNAK
QWKINKKRMC MLPAVKKKNF DFHEQRSLIL NLNLWKFIKF INCSSKNNYN KNNKHVRSSN
NTVKNENVLP LQKHKKVDND QRLENLFWRS WFKARKRRDI MGKPRERHIK FNDNVEQCII
TDEHFIQRLP STRLNSTDEQ RPCSKSELDP CIGNAASKRS FYDYNSVYVA SDAIITTAAA
TAIISSNSGD YQRGHDVRDV PRNVLLQAGE TDFSSVLRVD SDLKLSNISH HSPVKPSSTS
SHSTFIFESE TDTDTDTDAE TENDIDAYID TSIPNLLL
