ID   REG3_PYRHO              Reviewed;         158 AA.
AC   O57880;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator PH0140;
GN   OrderedLocusNames=PH0140;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- INTERACTION:
CC       O57880; O57880: PH0140; NbExp=2; IntAct=EBI-15665518, EBI-15665518;
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DR   EMBL; BA000001; BAA29209.1; -; Genomic_DNA.
DR   PIR; B71235; B71235.
DR   AlphaFoldDB; O57880; -.
DR   SMR; O57880; -.
DR   STRING; 70601.3256526; -.
DR   EnsemblBacteria; BAA29209; BAA29209; BAA29209.
DR   KEGG; pho:PH0140; -.
DR   eggNOG; arCOG01580; Archaea.
DR   OMA; NIFCKIR; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..158
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   PH0140"
FT                   /id="PRO_0000111762"
FT   DOMAIN          12..73
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   158 AA;  17928 MW;  8EBC6E37198BDB0D CRC64;
     MITVPHSRKV ELDEIDRAIL RLLQEDGRMS YSEISRRINV PESTVRARVN RLVKEGVIRK
     FAALINPFKA GYEIVAFIAV DAEPAKVKQV VEELAKFPEV DVLGIVTGAH DIFMQVTVKD
     LQELERFILE KMAKIDGIKS TETSILTSVK KWGYARVF