ID   REG4_RAT                Reviewed;         157 AA.
AC   Q68AX7;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Regenerating islet-derived protein 4;
DE            Short=REG-4;
DE   Flags: Precursor;
GN   Name=Reg4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Ileum;
RA   Namikawa K., Murakami K., Fukushima M., Kiyama H.;
RT   "Differential regulation of Reg family member expression after peripheral
RT   nerve injury.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-independent lectin displaying mannose-binding
CC       specificity and able to maintain carbohydrate recognition activity in
CC       an acidic environment. May be involved in inflammatory and metaplastic
CC       responses of the gastrointestinal epithelium (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AB164049; BAD38673.1; -; mRNA.
DR   RefSeq; NP_001004096.1; NM_001004096.1.
DR   RefSeq; XP_006233071.1; XM_006233009.3.
DR   RefSeq; XP_008759543.1; XM_008761321.2.
DR   RefSeq; XP_017446498.1; XM_017591009.1.
DR   AlphaFoldDB; Q68AX7; -.
DR   SMR; Q68AX7; -.
DR   STRING; 10116.ENSRNOP00000025821; -.
DR   GlyGen; Q68AX7; 3 sites.
DR   PaxDb; Q68AX7; -.
DR   Ensembl; ENSRNOT00000025821; ENSRNOP00000025821; ENSRNOG00000019046.
DR   GeneID; 445583; -.
DR   KEGG; rno:445583; -.
DR   UCSC; RGD:1303341; rat.
DR   CTD; 83998; -.
DR   RGD; 1303341; Reg4.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT00940000161011; -.
DR   HOGENOM; CLU_049894_10_1_1; -.
DR   InParanoid; Q68AX7; -.
DR   OMA; WNSNECN; -.
DR   OrthoDB; 1509611at2759; -.
DR   PhylomeDB; Q68AX7; -.
DR   PRO; PR:Q68AX7; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000019046; Expressed in jejunum and 11 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; ISO:RGD.
DR   GO; GO:2001065; F:mannan binding; ISO:RGD.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Lectin; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..157
FT                   /note="Regenerating islet-derived protein 4"
FT                   /id="PRO_0000017439"
FT   DOMAIN          36..154
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   BINDING         97..101
FT                   /ligand="a carbohydrate"
FT                   /ligand_id="ChEBI:CHEBI:16646"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..136
FT                   /ligand="a carbohydrate"
FT                   /ligand_id="ChEBI:CHEBI:16646"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        57..153
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        128..145
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   157 AA;  18269 MW;  55B129FB10BA4D1D CRC64;
     MASKCVRLLL LLSWVAGPEV LSDILRPSCA SGWFNYRSHC YGYFRKLRNW SHAELECQSY
     GNGSHLASVL NPKEASVISK YITGYQRSLP VWIGLHDPQK NASWQWIDGS TNQYRPWSPR
     TKSEARHCTE MNPKDKFLTW NKNGCTKRQH FLCKYRP