ID   REG5_DROME              Reviewed;         288 AA.
AC   Q94913; Q95RZ9; Q9W104;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Rhythmically expressed gene 5 protein;
DE   AltName: Full=dReg-5;
GN   Name=Reg-5; ORFNames=CG2928;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   STRAIN=Canton-S; TISSUE=Head;
RX   PubMed=8612586;
RA   van Gelder R.N., Krasnow M.A.;
RT   "A novel circadianly expressed Drosophila melanogaster gene dependent on
RT   the period gene for its rhythmic expression.";
RL   EMBO J. 15:1625-1631(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Involved in the generation of biological rhythms (Potential).
CC       In the head, oscillates in abundance with a daily peak during early
CC       night, even under constant darkness. Oscillation is dependent on period
CC       (per) function. {ECO:0000269|PubMed:8612586, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in head, but not in the body. Expression
CC       levels oscillate with the circadian rhythm.
CC       {ECO:0000269|PubMed:8612586}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in 24 hours embryo.
CC       {ECO:0000269|PubMed:8612586}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC47267.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAL28570.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR   EMBL; U65105; AAC47267.1; ALT_FRAME; mRNA.
DR   EMBL; AE013599; AAF47274.1; -; Genomic_DNA.
DR   EMBL; AY061022; AAL28570.1; ALT_SEQ; mRNA.
DR   EMBL; AY071459; AAL49081.1; -; mRNA.
DR   PIR; S69241; S69241.
DR   RefSeq; NP_001246504.1; NM_001259575.2.
DR   RefSeq; NP_477173.1; NM_057825.5.
DR   AlphaFoldDB; Q94913; -.
DR   STRING; 7227.FBpp0072332; -.
DR   PaxDb; Q94913; -.
DR   DNASU; 37968; -.
DR   EnsemblMetazoa; FBtr0072427; FBpp0072332; FBgn0015801.
DR   GeneID; 37968; -.
DR   KEGG; dme:Dmel_CG2928; -.
DR   CTD; 37968; -.
DR   FlyBase; FBgn0015801; Reg-5.
DR   VEuPathDB; VectorBase:FBgn0015801; -.
DR   eggNOG; ENOG502S4SS; Eukaryota.
DR   HOGENOM; CLU_1027682_0_0_1; -.
DR   InParanoid; Q94913; -.
DR   OMA; RNEKMSY; -.
DR   PhylomeDB; Q94913; -.
DR   BioGRID-ORCS; 37968; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Reg-5; fly.
DR   GenomeRNAi; 37968; -.
DR   PRO; PR:Q94913; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0015801; Expressed in oviduct (Drosophila) and 38 other tissues.
DR   ExpressionAtlas; Q94913; baseline and differential.
DR   Genevisible; Q94913; DM.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Rhythmically expressed gene 5 protein"
FT                   /id="PRO_0000097241"
FT   CONFLICT        193
FT                   /note="M -> V (in Ref. 1; AAC47267)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  31601 MW;  DDF91825C96C8AE1 CRC64;
     MTTAAKVILA CCLLGAFHIQ ISSSSAIPIW EFLTRNEKMS HLYSTFAQLV SVHCKSTAAV
     GGLPVNQCKH NLLGYGSAKL QTLSDVQLEA LDPYQRDANE LIWSSIMGDH PSGASLVTTR
     QPLQQPLPTP PASSLIILTR QQLPHGASHA HPIQSSGSAT NPIFESGEQK HKYAMDMDKA
     YGYGPQSSSE LPMAAALTSE PSKRFLTGPL VIRVRPDGSP VEEDKMMPLP RDEDLPYFHL
     GLAAAQPNRH RKIATISSLK QQHFASILQS DLQPPHQTQR RLFRQQQA