ID   REG7_PYRAB              Reviewed;         141 AA.
AC   Q9V159; G8ZJ35;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=HTH-type transcriptional regulator LrpA;
GN   Name=lrpA; OrderedLocusNames=PYRAB05700; ORFNames=PAB0392;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: DNA-binding protein that negatively regulates its own
CC       transcription. Interferes with RNA polymerase (RNAP) recruitment by
CC       inhibiting the association of RNAP with the TBP-TFB promoter complex.
CC       {ECO:0000250|UniProtKB:P42180}.
CC   -!- SUBUNIT: Homooctamer; tetramer of dimers.
CC       {ECO:0000250|UniProtKB:P42180}.
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DR   EMBL; AJ248284; CAB49492.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE69962.1; -; Genomic_DNA.
DR   PIR; E75176; E75176.
DR   RefSeq; WP_010867694.1; NC_000868.1.
DR   AlphaFoldDB; Q9V159; -.
DR   SMR; Q9V159; -.
DR   STRING; 272844.PAB0392; -.
DR   EnsemblBacteria; CAB49492; CAB49492; PAB0392.
DR   GeneID; 1495475; -.
DR   KEGG; pab:PAB0392; -.
DR   PATRIC; fig|272844.11.peg.608; -.
DR   eggNOG; arCOG01580; Archaea.
DR   HOGENOM; CLU_091233_5_4_2; -.
DR   OMA; EDCWFIA; -.
DR   OrthoDB; 97695at2157; -.
DR   PhylomeDB; Q9V159; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..141
FT                   /note="HTH-type transcriptional regulator LrpA"
FT                   /id="PRO_0000111770"
FT   DOMAIN          2..63
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   141 AA;  15861 MW;  A4B88CC855FC6D30 CRC64;
     MVDERDKIIL DILSKDARTP FTEIAKILGI SETAVRKRVK ALEEKGIIEG YTIKINPKKL
     GYSLVTITGV DTRPEKLFEV AEKLKEFEFV RELYLSSGDH MIMAVIWAKD GEDLADIISN
     KIGKIDGVTK VCPAIILERL K