ID   REG9_PYRFU              Reviewed;         150 AA.
AC   Q8U445;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-FEB-2004, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator PF0250;
GN   OrderedLocusNames=PF0250;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL80374.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE009950; AAL80374.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014835095.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U445; -.
DR   SMR; Q8U445; -.
DR   STRING; 186497.PF0250; -.
DR   PRIDE; Q8U445; -.
DR   EnsemblBacteria; AAL80374; AAL80374; PF0250.
DR   GeneID; 41712040; -.
DR   KEGG; pfu:PF0250; -.
DR   PATRIC; fig|186497.12.peg.261; -.
DR   eggNOG; arCOG01580; Archaea.
DR   HOGENOM; CLU_091233_5_4_2; -.
DR   OMA; IMECHMV; -.
DR   OrthoDB; 97695at2157; -.
DR   PhylomeDB; Q8U445; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..150
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   PF0250"
FT                   /id="PRO_0000111777"
FT   DOMAIN          5..66
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        24..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   150 AA;  16986 MW;  50DB76B5648370D4 CRC64;
     MAELLDRTDK MLLEELKKNA RENIAALSKK LGIPRTTVHY RIKRLLEEGI IEKFTIKPNY
     KKLNLGTTAF VLIRYDPDSG LTQKEVAEQI AKIPGVYEVH IVAGEWDILL KVRAANAEEV
     GKIVIEKLRE IKGVGQTVTM VSFVTIKEEI