ID   REGA_CLOAB              Reviewed;         334 AA.
AC   P58258;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=HTH-type transcriptional regulator RegA;
GN   Name=regA; OrderedLocusNames=CA_C3037;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: Involved in the regulation of amylase production.
CC       {ECO:0000250}.
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DR   EMBL; AE001437; AAK80977.1; -; Genomic_DNA.
DR   PIR; F97273; F97273.
DR   RefSeq; NP_349637.1; NC_003030.1.
DR   RefSeq; WP_010966318.1; NC_003030.1.
DR   AlphaFoldDB; P58258; -.
DR   SMR; P58258; -.
DR   STRING; 272562.CA_C3037; -.
DR   PRIDE; P58258; -.
DR   EnsemblBacteria; AAK80977; AAK80977; CA_C3037.
DR   GeneID; 44999524; -.
DR   KEGG; cac:CA_C3037; -.
DR   PATRIC; fig|272562.8.peg.3220; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; HSEFVFM; -.
DR   OrthoDB; 664909at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..334
FT                   /note="HTH-type transcriptional regulator RegA"
FT                   /id="PRO_0000107993"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   334 AA;  37423 MW;  B2CACD9F5998FD05 CRC64;
     MAASIKDVAR EARVSIATVS RVLNNVDVVN EETKKKVMEA IKKLDYRPNI VARSLKTQRT
     RTIGIVIPDI SSQFYPEIVR GAEDVSNIYN YNVILCNTDL DISKEKDYIR VLKEKMVDGV
     IYMSNSLAPE ILQLLRDLKI PTVLVETRES EDENAFPSVT IDNAKAAYDA VNYLIKKGNN
     KIAYVGVNPK LKNNARAIIY EGYKKALLDN NIPLNENLIQ FGGLKAIDGT DGINVIIKKE
     KIDAVFCACD EIAMGAINAL RENGIDVPKD VDVVGFDNIY TSSIFYPKLT TIEQPTYDMG
     SVGMRMLIKI INKAEPECLH YVLDYNIIER DSCK