ID   REGA_CLOSA              Reviewed;         332 AA.
AC   Q45831;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=HTH-type transcriptional regulator RegA;
GN   Name=regA; Synonyms=repA;
OS   Clostridium saccharobutylicum.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=169679;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-117 / DSM 13864 / NCP 262;
RX   PubMed=7539689; DOI=10.1099/13500872-141-4-989;
RA   Davison S.P., Santangelo J.D., Reid S.J., Woods D.R.;
RT   "A Clostridium acetobutylicum regulator gene (regA) affecting amylase
RT   production in Bacillus subtilis.";
RL   Microbiology 141:989-996(1995).
CC   -!- FUNCTION: Involved in the regulation of amylase production.
CC   -!- CAUTION: Was originally thought to originate from C.acetobutylicum.
CC       {ECO:0000305}.
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DR   EMBL; L14685; AAA23275.1; -; Genomic_DNA.
DR   RefSeq; WP_022743435.1; NZ_LZZA01000063.1.
DR   AlphaFoldDB; Q45831; -.
DR   SMR; Q45831; -.
DR   STRING; 169679.CSACC_00620; -.
DR   GeneID; 55472638; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..332
FT                   /note="HTH-type transcriptional regulator RegA"
FT                   /id="PRO_0000107994"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   332 AA;  37261 MW;  27CBE52FF9BEB007 CRC64;
     MATSIKDVAR EAGVSIATVS RVLNDIDVVN EDTKKKVLDA IKELGYRPNI VARSLKTQRT
     KTIGILLPDI SNQFYPEIVR GAEDVSNIYD YNIILCNSDL DIEKEKEYLR VLKEKMVDGV
     IYMSSSLRDE ILELINELDL KTVLVETRDK DGVLPSVTID NIKGSYDSTN LLIQKGIKDI
     AFIGTKKDNM NAWGDRYVGY EKAMNEAGIK IDPELLYLDS IKVKSGYEGI QHFLGLNKKF
     KGVVCASDDI AMGAINALRD NNMEVPKDVS VVGFNDNFAA SIFYPKITTV SQPTYDMGSV
     AMRMLIKLLN KKELDEPNYV LEHELIERES TI