ID   REGN_BPPH3              Reviewed;          99 AA.
AC   P07243;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   02-JUN-2021, entry version 62.
DE   RecName: Full=Probable regulatory protein N;
GN   Name=N;
OS   Enterobacteria phage phi21 (Bacteriophage phi-21).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae.
OX   NCBI_TaxID=10737;
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3157001; DOI=10.1016/0022-2836(85)90325-0;
RA   Franklin N.C.;
RT   "Conservation of genome form but not sequence in the transcription
RT   antitermination determinants of bacteriophages lambda, phi 21 and P22.";
RL   J. Mol. Biol. 181:75-84(1985).
CC   -!- FUNCTION: N protein regulates the transition from the early to the
CC       middle stage of lytic development.
CC   -!- MISCELLANEOUS: Protein N is an immediate early function essential for
CC       all other phage vegetative functions.
CC   -!- MISCELLANEOUS: Protein N is required to overcome termination of
CC       transcription.
CC   -!- MISCELLANEOUS: Protein N is effective in trans at a variety of
CC       terminators located at a distance from phage promoters, but absolutely
CC       dependent upon lambda-coded sites called nut, which must lie cis to the
CC       terminators acted upon.
CC   -!- MISCELLANEOUS: Protein N is type specific, in that the antitermination
CC       function of one lambdoid phage cannot, in general, complement a mutant
CC       function in another.
CC   -!- MISCELLANEOUS: Protein N is dependent upon host proteins, known by the
CC       existence of mutant host strains which block N function by their direct
CC       biochemical interaction with N and by the evidence for a recognition
CC       site for one of them (nusA) adjacent to the nut sites in the early
CC       operons of lambdoid phages.
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DR   EMBL; K03422; AAD15033.1; -; Genomic_DNA.
DR   PDB; 1NYB; NMR; -; A=8-29.
DR   PDBsum; 1NYB; -.
DR   SMR; P07243; -.
DR   EvolutionaryTrace; P07243; -.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Transcription; Transcription regulation;
KW   Transcription termination.
FT   CHAIN           1..99
FT                   /note="Probable regulatory protein N"
FT                   /id="PRO_0000077582"
FT   HELIX           13..25
FT                   /evidence="ECO:0007829|PDB:1NYB"
SQ   SEQUENCE   99 AA;  11151 MW;  CB4C3DC0F38AB756 CRC64;
     MVTIVWKESK GTAKSRYKAR RAELIAERRS NEALARKIAL KLSGCVRADK AASLGSLRCK
     KAEEVERKQN RIYYSKPRSE MGVTCVGRQK IKLGSKPLI