ID   REGX3_MYCBO             Reviewed;         227 AA.
AC   O07130; A0A1R3XVG3; X2BF91;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Sensory transduction protein RegX3;
GN   Name=regX3; OrderedLocusNames=BQ2027_MB0501;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG / Pasteur;
RX   PubMed=9426136; DOI=10.1046/j.1365-2958.1997.6361999.x;
RA   Supply P., Magdalena J., Himpens S., Locht C.;
RT   "Identification of novel intergenic repetitive units in a mycobacterial
RT   two-component system operon.";
RL   Mol. Microbiol. 26:991-1003(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Probably forms part of a two-component regulatory system
CC       RegX3/SenX3.
CC   -!- PTM: Phosphorylated by SenX3. {ECO:0000305}.
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DR   EMBL; Y13627; CAA73956.1; -; Genomic_DNA.
DR   EMBL; LT708304; SIT99096.1; -; Genomic_DNA.
DR   RefSeq; NP_854164.1; NC_002945.3.
DR   RefSeq; WP_003402393.1; NC_002945.4.
DR   AlphaFoldDB; O07130; -.
DR   SMR; O07130; -.
DR   GeneID; 45424452; -.
DR   PATRIC; fig|233413.5.peg.546; -.
DR   OMA; IDRVWGS; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..227
FT                   /note="Sensory transduction protein RegX3"
FT                   /id="PRO_0000081331"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        128..227
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   CONFLICT        18
FT                   /note="A -> T (in Ref. 1; CAA73956)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   227 AA;  24849 MW;  E005649EA7CA37F8 CRC64;
     MTSVLIVEDE ESLADPLAFL LRKEGFEATV VTDGPAALAE FDRAGADIVL LDLMLPGMSG
     TDVCKQLRAR SSVPVIMVTA RDSEIDKVVG LELGADDYVT KPYSARELIA RIRAVLRRGG
     DDDSEMSDGV LESGPVRMDV ERHVVSVNGD TITLPLKEFD LLEYLMRNSG RVLTRGQLID
     RVWGADYVGD TKTLDVHVKR LRSKIEADPA NPVHLVTVRG LGYKLEG