ID   REGX3_MYCLE             Reviewed;         198 AA.
AC   P54884;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Sensory transduction protein RegX3;
GN   Name=rgx3; OrderedLocusNames=ML2439; ORFNames=B2168_C3_248;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Probably forms part of a two-component regulatory system
CC       RegX3/SenX3.
CC   -!- PTM: Phosphorylated by SenX3. {ECO:0000305}.
CC   -!- CAUTION: To obtain a protein of the same size as its counterpart in
CC       other Mycobacteria, it would be necessary to introduce a frameshift. As
CC       both independent DNA sequences are identical, this seems to be a
CC       natural frameshift and the M.leprae sequence is therefore N-terminally
CC       truncated by about 30 residues. {ECO:0000305}.
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DR   EMBL; U00018; AAA17242.1; -; Genomic_DNA.
DR   EMBL; AL583925; CAC31956.1; -; Genomic_DNA.
DR   PIR; S72906; S72906.
DR   RefSeq; NP_302580.1; NC_002677.1.
DR   AlphaFoldDB; P54884; -.
DR   SMR; P54884; -.
DR   STRING; 272631.ML2439; -.
DR   EnsemblBacteria; CAC31956; CAC31956; CAC31956.
DR   KEGG; mle:ML2439; -.
DR   PATRIC; fig|272631.5.peg.4686; -.
DR   Leproma; ML2439; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_11; -.
DR   OMA; IDRVWGS; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..198
FT                   /note="Sensory transduction protein RegX3"
FT                   /id="PRO_0000081332"
FT   DOMAIN          1..87
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        99..198
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         23
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   198 AA;  21851 MW;  60C3DB466E3C6376 CRC64;
     MVTDGPAALA EFDRSGADIV LLDLMLPGMS GTDVYKQLRV RSSVPVIMVT ARDSEIDKVV
     GLELGADDYV TKPYSARELI ARIRAVLRRG GDDDSEISDG VLESGPLRMD VERHVVSVNG
     YAITLPLKEF DLLEYLMRNS GRVLTRGQLI DRVWGVDYVG DTKTLDVHVK RLRSKIEADP
     ANPVHLVTVR GLGYKLES