ID   REGX3_MYCTO             Reviewed;         227 AA.
AC   P9WGL8; L0T3S2; Q11156;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Sensory transduction protein RegX3;
GN   Name=regX3; OrderedLocusNames=MT0510;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Probably forms part of a two-component regulatory system
CC       RegX3/SenX3. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by SenX3. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK44733.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK44733.1; ALT_INIT; Genomic_DNA.
DR   PIR; F70744; F70744.
DR   RefSeq; WP_003402393.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGL8; -.
DR   SMR; P9WGL8; -.
DR   EnsemblBacteria; AAK44733; AAK44733; MT0510.
DR   GeneID; 45424452; -.
DR   KEGG; mtc:MT0510; -.
DR   PATRIC; fig|83331.31.peg.540; -.
DR   HOGENOM; CLU_000445_30_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..227
FT                   /note="Sensory transduction protein RegX3"
FT                   /id="PRO_0000428339"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        128..227
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   227 AA;  24849 MW;  E005649EA7CA37F8 CRC64;
     MTSVLIVEDE ESLADPLAFL LRKEGFEATV VTDGPAALAE FDRAGADIVL LDLMLPGMSG
     TDVCKQLRAR SSVPVIMVTA RDSEIDKVVG LELGADDYVT KPYSARELIA RIRAVLRRGG
     DDDSEMSDGV LESGPVRMDV ERHVVSVNGD TITLPLKEFD LLEYLMRNSG RVLTRGQLID
     RVWGADYVGD TKTLDVHVKR LRSKIEADPA NPVHLVTVRG LGYKLEG