ID   REGX3_MYCTU             Reviewed;         227 AA.
AC   P9WGL9; L0T3S2; Q11156;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Sensory transduction protein RegX3;
GN   Name=regX3; OrderedLocusNames=Rv0491; ORFNames=MTCY20G9.17;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=2296207;
RX   PubMed=9426136; DOI=10.1046/j.1365-2958.1997.6361999.x;
RA   Supply P., Magdalena J., Himpens S., Locht C.;
RT   "Identification of novel intergenic repetitive units in a mycobacterial
RT   two-component system operon.";
RL   Mol. Microbiol. 26:991-1003(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Probably forms part of a two-component regulatory system
CC       RegX3/SenX3.
CC   -!- PTM: Phosphorylated by SenX3. {ECO:0000305}.
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DR   EMBL; Y13628; CAA73958.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP43225.1; -; Genomic_DNA.
DR   PIR; F70744; F70744.
DR   RefSeq; NP_215005.1; NC_000962.3.
DR   RefSeq; WP_003402393.1; NZ_NVQJ01000002.1.
DR   PDB; 2OQR; X-ray; 2.03 A; A=2-227.
DR   PDBsum; 2OQR; -.
DR   AlphaFoldDB; P9WGL9; -.
DR   SMR; P9WGL9; -.
DR   STRING; 83332.Rv0491; -.
DR   PaxDb; P9WGL9; -.
DR   DNASU; 887195; -.
DR   GeneID; 45424452; -.
DR   GeneID; 887195; -.
DR   KEGG; mtu:Rv0491; -.
DR   TubercuList; Rv0491; -.
DR   eggNOG; COG0745; Bacteria.
DR   OMA; IDRVWGS; -.
DR   PhylomeDB; P9WGL9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IDA:MTBBASE.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0019220; P:regulation of phosphate metabolic process; IDA:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MTBBASE.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..227
FT                   /note="Sensory transduction protein RegX3"
FT                   /id="PRO_0000081334"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        128..227
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          3..7
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           11..23
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          27..31
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           34..44
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          47..54
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          56..58
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           60..70
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          74..79
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           82..93
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           105..116
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   TURN            117..120
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          131..133
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          136..139
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   TURN            140..143
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          144..150
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           156..167
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   TURN            168..170
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           175..182
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   HELIX           190..205
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          207..211
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          213..218
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   TURN            219..221
FT                   /evidence="ECO:0007829|PDB:2OQR"
FT   STRAND          222..225
FT                   /evidence="ECO:0007829|PDB:2OQR"
SQ   SEQUENCE   227 AA;  24849 MW;  E005649EA7CA37F8 CRC64;
     MTSVLIVEDE ESLADPLAFL LRKEGFEATV VTDGPAALAE FDRAGADIVL LDLMLPGMSG
     TDVCKQLRAR SSVPVIMVTA RDSEIDKVVG LELGADDYVT KPYSARELIA RIRAVLRRGG
     DDDSEMSDGV LESGPVRMDV ERHVVSVNGD TITLPLKEFD LLEYLMRNSG RVLTRGQLID
     RVWGADYVGD TKTLDVHVKR LRSKIEADPA NPVHLVTVRG LGYKLEG