ID   REL1_PANTR              Reviewed;         166 AA.
AC   P51454;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Prorelaxin H1;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
DE   Flags: Precursor; Fragment;
GN   Name=RNL1; Synonyms=RLX1;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=8182365; DOI=10.1677/joe.0.1400385;
RA   Evans B.A., Fu P., Tregear G.W.;
RT   "Characterization of two relaxin genes in the chimpanzee.";
RL   J. Endocrinol. 140:385-392(1994).
CC   -!- FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to
CC       produce dilatation of the birth canal in many mammals. May be involved
CC       in remodeling of connective tissues during pregnancy, promoting growth
CC       of pubic ligaments and ripening of the cervix.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the corpus luteum of pregnancy but not
CC       in the placenta.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; Z27225; CAA81739.1; -; mRNA.
DR   PIR; S42783; S42783.
DR   AlphaFoldDB; P51454; -.
DR   SMR; P51454; -.
DR   STRING; 9598.ENSPTRP00000054896; -.
DR   PaxDb; P51454; -.
DR   eggNOG; ENOG502TH8D; Eukaryota.
DR   InParanoid; P51454; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   InterPro; IPR022421; Relaxin.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   PRINTS; PR02004; RELAXIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          <1..5
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         6..34
FT                   /note="Relaxin B chain"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016106"
FT   PROPEP          37..139
FT                   /note="Connecting peptide"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016107"
FT   PEPTIDE         143..166
FT                   /note="Relaxin A chain"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016108"
FT   DISULFID        16..153
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        28..166
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        152..157
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   166 AA;  18731 MW;  7F469B1FB9259F4F CRC64;
     SRAVADSWMD EVIKLCGREL VRAQIAICGM STWSKRSLSQ EDAPQTPRPV AEIVPSFINK
     DTETIIIMLE FIANLPPELK AALSERQPSL PEPQQYVPAL KDSNLSFEEF KKLIRNRQSE
     AADSNPSELK YLGLDTHSQK KRQPYVALFE KCCLIGCTKR SLANYC