REL2_PANTR
ID REL2_PANTR Reviewed; 166 AA.
AC P51455; P79267;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Prorelaxin H2;
DE Contains:
DE RecName: Full=Relaxin B chain;
DE Contains:
DE RecName: Full=Relaxin A chain;
DE Flags: Precursor; Fragment;
GN Name=RNL2; Synonyms=RLX2;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=8182365; DOI=10.1677/joe.0.1400385;
RA Evans B.A., Fu P., Tregear G.W.;
RT "Characterization of two relaxin genes in the chimpanzee.";
RL J. Endocrinol. 140:385-392(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 52-166 (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Ovary, and Placenta;
RX PubMed=8735594; DOI=10.1016/0303-7207(96)03770-7;
RA Gunnersen J.M., Fu P., Roche P.J., Tregear G.W.;
RT "Expression of human relaxin genes: characterization of a novel
RT alternatively-spliced human relaxin mRNA species.";
RL Mol. Cell. Endocrinol. 118:85-94(1996).
CC -!- FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to
CC produce dilatation of the birth canal in many mammals. May be involved
CC in remodeling of connective tissues during pregnancy, promoting growth
CC of pubic ligaments and ripening of the cervix.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P51455-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P51455-2; Sequence=VSP_002713, VSP_002714;
CC -!- TISSUE SPECIFICITY: Expressed in the corpus luteum of pregnancy and in
CC the placenta. {ECO:0000269|PubMed:8182365, ECO:0000269|PubMed:8735594}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; Z27245; CAA81758.1; -; mRNA.
DR EMBL; S83209; AAD14430.1; ALT_SEQ; mRNA.
DR PIR; S42786; S42786.
DR AlphaFoldDB; P51455; -.
DR SMR; P51455; -.
DR STRING; 9598.ENSPTRP00000060253; -.
DR PaxDb; P51455; -.
DR InParanoid; P51455; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR InterPro; IPR022421; Relaxin.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR PRINTS; PR02004; RELAXIN.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cleavage on pair of basic residues; Disulfide bond;
KW Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL <1..5
FT /evidence="ECO:0000250"
FT PEPTIDE 6..34
FT /note="Relaxin B chain"
FT /evidence="ECO:0000250"
FT /id="PRO_0000016109"
FT PROPEP 37..138
FT /note="Connecting peptide"
FT /evidence="ECO:0000250"
FT /id="PRO_0000016110"
FT PEPTIDE 143..166
FT /note="Relaxin A chain"
FT /evidence="ECO:0000250"
FT /id="PRO_0000016111"
FT DISULFID 16..153
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 28..166
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 152..157
FT /evidence="ECO:0000250"
FT VAR_SEQ 52..98
FT /note="EIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQYVP -> G
FT DFIQTVSLGISPDGGKALRTGSCFTREFLGALSKLCHPSSTKIQKP (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:8735594"
FT /id="VSP_002713"
FT VAR_SEQ 99..166
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8735594"
FT /id="VSP_002714"
FT VARIANT 30..34
FT /note="KSTWS -> MSTLG (in some alleles)"
FT /id="VAR_018717"
FT NON_TER 1
SQ SEQUENCE 166 AA; 18761 MW; 220851E3134CEBDB CRC64;
SRAVADSWMD EVIKLCGREL VRAQIAICGK STWSKRSLSQ EDAPQTPRPV AEIVPSFINK
DTETINMMSE FVANLPQELK LTLSEMQPAL PQLQQYVPVL KDSSLLFEEF KKLIRNRQSE
AADSSPSELK YLGLDTHSRK KRQLYSALAN KCCHVGCTKR SLARFC
