ID   RELB1_CAUVC             Reviewed;          87 AA.
AC   Q9AA08;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Antitoxin RelB1;
GN   Name=relB1; OrderedLocusNames=CC_0803;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS AN ANTITOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of cognate toxin RelE1, but no other RelE or
CC       ParE toxin. {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: Cannot be disrupted, suggesting it is a
CC       functional antitoxin. No visible phenotype when the relBE1 operon is
CC       deleted. {ECO:0000269|PubMed:20487277}.
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DR   EMBL; AE005673; AAK22788.1; -; Genomic_DNA.
DR   PIR; H87348; H87348.
DR   RefSeq; NP_419620.1; NC_002696.2.
DR   RefSeq; WP_010918688.1; NC_002696.2.
DR   AlphaFoldDB; Q9AA08; -.
DR   SMR; Q9AA08; -.
DR   STRING; 190650.CC_0803; -.
DR   EnsemblBacteria; AAK22788; AAK22788; CC_0803.
DR   KEGG; ccr:CC_0803; -.
DR   PATRIC; fig|190650.5.peg.815; -.
DR   HOGENOM; CLU_2477681_0_0_5; -.
DR   BioCyc; CAULO:CC0803-MON; -.
DR   Proteomes; UP000001816; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..87
FT                   /note="Antitoxin RelB1"
FT                   /id="PRO_0000408464"
SQ   SEQUENCE   87 AA;  9198 MW;  1506C1096F869DD6 CRC64;
     MADGFDIHID QEQAARLKVV ADRLGMSVSE YAVALIDAGL TGAAPKAIDP DPAIDEAIAD
     AIERGDEPAI SRDEFRAHIR RVTAGLG