ID   RELB3_CAUVC             Reviewed;         117 AA.
AC   Q9A4F5;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Antitoxin RelB3;
GN   Name=relB3; OrderedLocusNames=CC_2879;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS AN ANTITOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of cognate toxin RelE3, but no other RelE or
CC       ParE toxin. {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: Cannot be disrupted, suggesting it is a
CC       functional antitoxin. No visible phenotype when the relBE3 operon is
CC       deleted. {ECO:0000269|PubMed:20487277}.
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DR   EMBL; AE005673; AAK24843.1; -; Genomic_DNA.
DR   PIR; G87605; G87605.
DR   RefSeq; NP_421675.1; NC_002696.2.
DR   AlphaFoldDB; Q9A4F5; -.
DR   SMR; Q9A4F5; -.
DR   STRING; 190650.CC_2879; -.
DR   EnsemblBacteria; AAK24843; AAK24843; CC_2879.
DR   KEGG; ccr:CC_2879; -.
DR   PATRIC; fig|190650.5.peg.2883; -.
DR   HOGENOM; CLU_2080543_0_0_5; -.
DR   OMA; ICDETER; -.
DR   BioCyc; CAULO:CC2879-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0009432; P:SOS response; EXP:CollecTF.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..117
FT                   /note="Antitoxin RelB3"
FT                   /id="PRO_0000408466"
SQ   SEQUENCE   117 AA;  13275 MW;  7CCC6302B4D95258 CRC64;
     MSGVIAPDRV DDKRRMEHSQ NMALTITIPA ELASRLRASA EAEGKDVDAY AIDALHVMSD
     EDWGYTDDDA YWRELRAHSD EVRRDGGIPL EDVKRWVASW DTENELPPPE PRIKARG