ID   RELB3_METJA             Reviewed;          53 AA.
AC   P0CL56;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Antitoxin RelB3;
GN   Name=relB3; Synonyms=relB; OrderedLocusNames=MJ1103.1;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-52, AND SUBUNIT.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=19712680; DOI=10.1016/j.jmb.2009.08.048;
RA   Francuski D., Saenger W.;
RT   "Crystal structure of the antitoxin-toxin protein complex RelB-RelE from
RT   Methanococcus jannaschii.";
RL   J. Mol. Biol. 393:898-908(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Probably neutralizes the toxic activity of cognate toxin RelE (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms heterodimers with RelE and possibly a heterotetramer
CC       RelE3-RelB3(2)-RelE3 from 2 heterodimers. The heterotetramer is
CC       probably not very stable in solution. {ECO:0000269|PubMed:19712680}.
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DR   EMBL; L77117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PDB; 3BPQ; X-ray; 2.20 A; A/C=1-52.
DR   PDBsum; 3BPQ; -.
DR   AlphaFoldDB; P0CL56; -.
DR   SMR; P0CL56; -.
DR   EvolutionaryTrace; P0CL56; -.
DR   Proteomes; UP000000805; Chromosome.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..53
FT                   /note="Antitoxin RelB3"
FT                   /id="PRO_0000406203"
FT   HELIX           14..33
FT                   /evidence="ECO:0007829|PDB:3BPQ"
FT   TURN            34..37
FT                   /evidence="ECO:0007829|PDB:3BPQ"
FT   HELIX           43..47
FT                   /evidence="ECO:0007829|PDB:3BPQ"
SQ   SEQUENCE   53 AA;  6440 MW;  6F309BD5CBD5CF5F CRC64;
     MRLKKRFKKF FISRKEYEKI EEILDIGLAK AMEETKDDEL LTYDEIKELL GDK