RELB4_CAUVC
ID RELB4_CAUVC Reviewed; 59 AA.
AC P0CW75;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=Antitoxin RelB4;
GN Name=relB4; OrderedLocusNames=CC_3130.1;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN [2]
RP IDENTIFICATION, AND POSSIBLE FUNCTION.
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=15718296; DOI=10.1093/nar/gki201;
RA Pandey D.P., Gerdes K.;
RT "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT host-associated prokaryotes.";
RL Nucleic Acids Res. 33:966-976(2005).
RN [3]
RP FUNCTION AS AN ANTITOXIN, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT "Interaction specificity, toxicity and regulation of a paralogous set of
RT ParE/RelE-family toxin-antitoxin systems.";
RL Mol. Microbiol. 77:236-251(2010).
CC -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC Neutralizes the effect of cognate toxin RelE4, but no other RelE or
CC ParE toxin. {ECO:0000269|PubMed:20487277}.
CC -!- DISRUPTION PHENOTYPE: Cannot be disrupted, suggesting it is a
CC functional antitoxin. No visible phenotype when the relBE4 operon is
CC deleted. {ECO:0000269|PubMed:20487277}.
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DR EMBL; AE005673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; WP_012640671.1; NC_002696.2.
DR AlphaFoldDB; P0CW75; -.
DR SMR; P0CW75; -.
DR Proteomes; UP000001816; Chromosome.
PE 1: Evidence at protein level;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..59
FT /note="Antitoxin RelB4"
FT /id="PRO_0000408467"
FT REGION 38..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 59 AA; 6606 MW; 01BE9A353B75293D CRC64;
MAEPDPDIFD EDDEAILAAD AEADADFEAG RTVPHERVGE WLKTLGTPHQ TPPPYSWRK