RELB_CHICK
ID RELB_CHICK Reviewed; 549 AA.
AC P51509; Q90721; Q9PWF4;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transcription factor RelB homolog;
GN Name=RELB;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE NF-KAPPA-B RELB-P50
RP COMPLEX, AND IDENTIFICATION IN THE NF-KAPPA-B RELB-P52 COMPLEX.
RC TISSUE=Spleen;
RX PubMed=11529676; DOI=10.1006/mcbr.2001.0290;
RA Piffat K.A., Hrdlickova R., Nehyba J., Ikeda T., Liss A., Huang S., Sif S.,
RA Gilmore T.D., Bose H.R. Jr.;
RT "The chicken RelB transcription factor has transactivation sequences and a
RT tissue-specific expression pattern that are distinct from mammalian RelB.";
RL Mol. Cell Biol. Res. Commun. 4:266-275(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 151-424.
RC TISSUE=Spleen;
RA Ikeda T.;
RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 150-479.
RA Gilmore T.D., Piffat K.A., Huang S., Sif S.;
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NF-kappa-B is a pleiotropic transcription factor which is
CC present in almost all cell types and is involved in many biological
CC processed such as inflammation, immunity, differentiation, cell growth,
CC tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
CC complex formed by the Rel-like domain-containing proteins RELA/p65,
CC RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at
CC kappa-B sites in the DNA of their target genes and the individual
CC dimers have distinct preferences for different kappa-B sites that they
CC can bind with distinguishable affinity and specificity. Different dimer
CC combinations act as transcriptional activators or repressors,
CC respectively. NF-kappa-B is controlled by various mechanisms of post-
CC translational modification and subcellular compartmentalization as well
CC as by interactions with other cofactors or corepressors. NF-kappa-B
CC complexes are held in the cytoplasm in an inactive state complexed with
CC members of the NF-kappa-B inhibitor (I-kappa-B) family. In a
CC conventional activation pathway, I-kappa-B is phosphorylated by I-
CC kappa-B kinases (IKKs) in response to different activators,
CC subsequently degraded thus liberating the active NF-kappa-B complex
CC which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50
CC and RelB-p52 complexes are transcriptional activators. Stimulates
CC promoter activity in the presence of p49- and p50-NF-kappa-B. Neither
CC associates with DNA nor with p65-NF-kappa-B. May play a role in the
CC regulation of the circadian clock (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NF-kappa-B RelB-p50 complex. Component of the
CC NF-kappa-B RelB-p52 complex. {ECO:0000269|PubMed:11529676}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; AF029260; AAD41539.1; -; mRNA.
DR EMBL; D13794; BAA02947.1; -; mRNA.
DR EMBL; U51737; AAA96827.1; -; mRNA.
DR AlphaFoldDB; P51509; -.
DR SMR; P51509; -.
DR VEuPathDB; HostDB:geneid_396500; -.
DR InParanoid; P51509; -.
DR PhylomeDB; P51509; -.
DR PRO; PR:P51509; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0038061; P:NIK/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.340; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR030496; RelB.
DR InterPro; IPR032400; RelB_transact.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169; PTHR24169; 1.
DR PANTHER; PTHR24169:SF18; PTHR24169:SF18; 1.
DR Pfam; PF16181; RelB_transactiv; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 1: Evidence at protein level;
KW Activator; Biological rhythms; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..549
FT /note="Transcription factor RelB homolog"
FT /id="PRO_0000205175"
FT DOMAIN 135..412
FT /note="RHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00265"
FT REGION 100..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 266
FT /note="G -> A (in Ref. 1; AAD41539)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="A -> G (in Ref. 2; BAA02947)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="G -> E (in Ref. 2; BAA02947)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="R -> A (in Ref. 3; AAA96827)"
FT /evidence="ECO:0000305"
FT CONFLICT 479
FT /note="S -> F (in Ref. 3; AAA96827)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 549 AA; 60193 MW; 1766BCF2C78BA37D CRC64;
MFAPSLAAFR AMALPIPRLA PVMKSVQPAS FPVLGSMAAR LSTARGGRGL RAGRRPPGGP
KGAAAAEEMA VPIGAALQDP NVGMAPVNDD LEIIEEVMKE DGFQPDPPPP GSPHDPPKLI
PRGLGVPVGR RDPPRDPPRL IITEQPKKTG MRFRYECEGR SAGSILGESS TEASKTLPAI
ELLNCQAIPE VQVTACLVWK DWPHRVHPHG LVGKDCSNGL CQVRLQPHAN PRHSFSNLGI
QCVKKKEIEA AIEKKLQLGI DPFKAGSLKN HQEVDMNVVR ICFQASYRDG SGRTRQLSPV
LSEPIFDKKS TNTSELRICR MNKESGPCTG GEELYLLCDK VQKEDIAVVF RKEPWEARAD
FSQADVHRQG AIVLRTPPYR CVQLSEPVQV EVFLQRLTDR ARSRGCPYTY LPRERDAYGV
KVKRKRGMPD LLEELSGADP YGIEAKRRKP PPGFMDHFAP LPAADEAFAL LADPLDPLSH
LPPPSTPQIL WGRSYFRTPP PTETPTPPTA SWGPICSQGT SEGGGGRTSP RYRPPPPLKW
GSQWAPPHQ
