ID   RELB_SHIFL              Reviewed;          79 AA.
AC   P0C080; P07007;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Antitoxin RelB;
GN   Name=relB; Synonyms=relB1; OrderedLocusNames=SF1549, S1670;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
RN   [3]
RP   POSSIBLE FUNCTION.
RC   STRAIN=301 / Serotype 2a, and ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Counteracts the effect of RelE via direct protein-protein interaction,
CC       enabling the reversion of translation inhibition. Also acts as an
CC       autorepressor of relBE transcription. Increased transcription rate of
CC       relBE and activation of relE is consistent with a lower level of RelB
CC       in starved cells due to degradation of RelB by protease Lon (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probably a homotetramer in solution. Binds DNA as a RelE(2)-
CC       RelB(2) heterotetramer (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RelB/DinJ antitoxin family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN43138.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17029.1; -; Genomic_DNA.
DR   RefSeq; NP_707431.1; NC_004337.2.
DR   RefSeq; WP_000534858.1; NZ_WPGV01000221.1.
DR   AlphaFoldDB; P0C080; -.
DR   BMRB; P0C080; -.
DR   SMR; P0C080; -.
DR   STRING; 198214.SF1549; -.
DR   EnsemblBacteria; AAN43138; AAN43138; SF1549.
DR   EnsemblBacteria; AAP17029; AAP17029; S1670.
DR   GeneID; 1024732; -.
DR   GeneID; 39497046; -.
DR   GeneID; 67515104; -.
DR   KEGG; sfl:SF1549; -.
DR   KEGG; sfx:S1670; -.
DR   PATRIC; fig|198214.7.peg.1831; -.
DR   HOGENOM; CLU_169573_0_0_6; -.
DR   OMA; TINIRVN; -.
DR   OrthoDB; 2086657at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR007337; RelB/DinJ.
DR   PANTHER; PTHR38781; PTHR38781; 1.
DR   Pfam; PF04221; RelB; 1.
DR   TIGRFAMs; TIGR02384; RelB_DinJ; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Stress response;
KW   Toxin-antitoxin system; Transcription; Transcription regulation.
FT   CHAIN           1..79
FT                   /note="Antitoxin RelB"
FT                   /id="PRO_0000097244"
SQ   SEQUENCE   79 AA;  9071 MW;  3DD2107337226FAD CRC64;
     MGSINLRIDD ELKARSYAAL EKMGVTPSEA LRLMLEYIAD NERLPFKQTL LSDEDAELVE
     IVKERLRNPK PVRVTLDEL