RELB_XENLA
ID RELB_XENLA Reviewed; 497 AA.
AC P51510;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transcription factor RelB homolog;
GN Name=relb;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=8524658; DOI=10.1093/nar/23.22.4664;
RA Suzuki K., Yamamoto T., Inoue J.;
RT "Molecular cloning of cDNA encoding the Xenopus homolog of mammalian
RT RelB.";
RL Nucleic Acids Res. 23:4664-4669(1995).
CC -!- FUNCTION: Does not bind DNA by itself; probably associates with a p50-
CC NF-kappa-B homolog to act as an activator. Could be involved in
CC hematopoiesis and spleen development. May play a role in the regulation
CC of the circadian clock.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D63332; BAA09646.1; -; mRNA.
DR PIR; S60161; S60161.
DR RefSeq; NP_001079335.1; NM_001085866.1.
DR AlphaFoldDB; P51510; -.
DR SMR; P51510; -.
DR PRIDE; P51510; -.
DR GeneID; 378663; -.
DR KEGG; xla:378663; -.
DR CTD; 378663; -.
DR Xenbase; XB-GENE-6068550; relb.S.
DR OrthoDB; 916931at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 378663; Expressed in spleen and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.340; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR030496; RelB.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169; PTHR24169; 1.
DR PANTHER; PTHR24169:SF18; PTHR24169:SF18; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Biological rhythms; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..497
FT /note="Transcription factor RelB homolog"
FT /id="PRO_0000205176"
FT DOMAIN 78..393
FT /note="RHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00265"
FT REGION 359..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 386..391
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 497 AA; 56246 MW; 645C8BA54C0F9D64 CRC64;
MREQGREGSS FLSQQLGPTI EDVMDLINSD RDVISSPSVF VCEDAPSSIL STVTVAHYVP
HEQCPSTSWA PQREGPNPEL NITEQPKQRG MRFRYQCEGR STGSILGEKS TEHNKTLPEI
EIINCDGLEE IHVIVCLVWR DPPHRVHPHG LVGKDCHNGI CEVTLNPQNG VAKHSFSNLG
IQCVRKREID SAVNERLKLN IDPYKAGKWR LHEEVDLNVV RLCFQASCTG PGFKYDIPPV
LSDPIYDKKS TNTSELKISR MNKEYGRCEG GEEVYILCDK VQKEDILVIF GEDKWEARAD
FSQADVHRQI AIVLKTPPYH DLHITEPACV RVFLQRITDG IRSEGMPFVY MPRVKDPNGV
HSKRKHRDCS QLGDIGDPDP HGIEMKRRKV RPSYADHLIP PYPDINLPLM DSFNHNEGYH
DLPLMNPDED AFHFLTEDPH FSDLLTHDPY FLDGYSNQFL PDQVNGVTAH LVGSSLALTD
EEQPLPDCAF NDSGCRR