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RELB_XENLA
ID   RELB_XENLA              Reviewed;         497 AA.
AC   P51510;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Transcription factor RelB homolog;
GN   Name=relb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=8524658; DOI=10.1093/nar/23.22.4664;
RA   Suzuki K., Yamamoto T., Inoue J.;
RT   "Molecular cloning of cDNA encoding the Xenopus homolog of mammalian
RT   RelB.";
RL   Nucleic Acids Res. 23:4664-4669(1995).
CC   -!- FUNCTION: Does not bind DNA by itself; probably associates with a p50-
CC       NF-kappa-B homolog to act as an activator. Could be involved in
CC       hematopoiesis and spleen development. May play a role in the regulation
CC       of the circadian clock.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; D63332; BAA09646.1; -; mRNA.
DR   PIR; S60161; S60161.
DR   RefSeq; NP_001079335.1; NM_001085866.1.
DR   AlphaFoldDB; P51510; -.
DR   SMR; P51510; -.
DR   PRIDE; P51510; -.
DR   GeneID; 378663; -.
DR   KEGG; xla:378663; -.
DR   CTD; 378663; -.
DR   Xenbase; XB-GENE-6068550; relb.S.
DR   OrthoDB; 916931at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 378663; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd01177; IPT_NFkappaB; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.340; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR033926; IPT_NFkappaB.
DR   InterPro; IPR000451; NFkB/Dor.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR030496; RelB.
DR   InterPro; IPR030492; RHD_CS.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR24169; PTHR24169; 1.
DR   PANTHER; PTHR24169:SF18; PTHR24169:SF18; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR00057; NFKBTNSCPFCT.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS01204; REL_1; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Biological rhythms; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..497
FT                   /note="Transcription factor RelB homolog"
FT                   /id="PRO_0000205176"
FT   DOMAIN          78..393
FT                   /note="RHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00265"
FT   REGION          359..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           386..391
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   497 AA;  56246 MW;  645C8BA54C0F9D64 CRC64;
     MREQGREGSS FLSQQLGPTI EDVMDLINSD RDVISSPSVF VCEDAPSSIL STVTVAHYVP
     HEQCPSTSWA PQREGPNPEL NITEQPKQRG MRFRYQCEGR STGSILGEKS TEHNKTLPEI
     EIINCDGLEE IHVIVCLVWR DPPHRVHPHG LVGKDCHNGI CEVTLNPQNG VAKHSFSNLG
     IQCVRKREID SAVNERLKLN IDPYKAGKWR LHEEVDLNVV RLCFQASCTG PGFKYDIPPV
     LSDPIYDKKS TNTSELKISR MNKEYGRCEG GEEVYILCDK VQKEDILVIF GEDKWEARAD
     FSQADVHRQI AIVLKTPPYH DLHITEPACV RVFLQRITDG IRSEGMPFVY MPRVKDPNGV
     HSKRKHRDCS QLGDIGDPDP HGIEMKRRKV RPSYADHLIP PYPDINLPLM DSFNHNEGYH
     DLPLMNPDED AFHFLTEDPH FSDLLTHDPY FLDGYSNQFL PDQVNGVTAH LVGSSLALTD
     EEQPLPDCAF NDSGCRR
 
 
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