ID   RELCH_DANRE             Reviewed;        1189 AA.
AC   Q6P6Y1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=RAB11-binding protein RELCH homolog;
DE   AltName: Full=LisH domain and HEAT repeat-containing protein KIAA1468;
DE   AltName: Full=RAB11-binding and LisH domain, coiled-coil and HEAT repeat-containing protein RELCH;
GN   Name=relch; ORFNames=zgc:66014;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate intracellular cholesterol transport.
CC       {ECO:0000250|UniProtKB:Q9P260}.
CC   -!- SUBCELLULAR LOCATION: Recycling endosome
CC       {ECO:0000250|UniProtKB:Q9P260}. Golgi apparatus, trans-Golgi network
CC       {ECO:0000250|UniProtKB:Q9P260}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC061956; AAH61956.1; -; mRNA.
DR   RefSeq; NP_957138.1; NM_200844.1.
DR   AlphaFoldDB; Q6P6Y1; -.
DR   STRING; 7955.ENSDARP00000055445; -.
DR   PaxDb; Q6P6Y1; -.
DR   GeneID; 393817; -.
DR   KEGG; dre:393817; -.
DR   CTD; 57614; -.
DR   ZFIN; ZDB-GENE-040426-1507; relch.
DR   eggNOG; KOG0211; Eukaryota.
DR   InParanoid; Q6P6Y1; -.
DR   OrthoDB; 73423at2759; -.
DR   PhylomeDB; Q6P6Y1; -.
DR   PRO; PR:Q6P6Y1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0032367; P:intracellular cholesterol transport; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR040362; RELCH.
DR   PANTHER; PTHR32059; PTHR32059; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   SMART; SM00667; LisH; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Golgi apparatus; Lipid transport;
KW   Reference proteome; Repeat; Transport.
FT   CHAIN           1..1189
FT                   /note="RAB11-binding protein RELCH homolog"
FT                   /id="PRO_0000313095"
FT   DOMAIN          229..261
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REPEAT          574..612
FT                   /note="HEAT 1"
FT                   /evidence="ECO:0000305"
FT   REPEAT          613..652
FT                   /note="HEAT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00103"
FT   REPEAT          977..1015
FT                   /note="HEAT 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00103"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..205
FT                   /evidence="ECO:0000255"
FT   COILED          326..373
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        14..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1189 AA;  132131 MW;  128129EAE270FDD7 CRC64;
     MAAGNVNPFN VSDSEEEAEQ RQDGADTERS PSDEAQGHSL GPFSPPAYSD PAALLSSNRT
     SPSVDGIPAS AAAVSGIGAE TRVSLDAIAA QLLRDQYILT ALELHTELLE AGRELPRLRD
     YFSNPGNFER QSGTPPACKE QGVGPGGPLN RAGSISTLDS LDFARYSDDG NRESDERVAV
     LEFELRKAKE TIQALRANLT QAAECEIASQ ERKNYKSSPE TQEPIRPLEK RALNFLVNEY
     LLKNEYKLTS ITFSDENDDQ DFELWDDVGL NIPKPPDLLQ LYRNCGNSQP LHRDTVDVAV
     SVDPSDLPAD YFTQEPVQQT DVIQQQQQQE VVQELEYQIS LLNSEKQSLA EQIKKLQSDI
     QALQRNVSSE LTAGVKSIQS KENPKCDKPP LDNGQYLDIR GVTETDSSSD TTKTSTSTTI
     ATDCTENSTT ATQPHSKLKA NGQQSKSSVQ FDQPNRKLSP AFHQALLSFC RMSADSRLGS
     EVSRIADSEQ SVMLMLGRCL PHIVPNVLLA KREELIPLIL CTACLHPEPK ERDQLLHILF
     NLIKRPDDEQ RQMILTGCVA FAQHVGPTRV EAELLPQCWE QINHKYPERR LLVAEACGAL
     APYLPKEIRS SLVLSMLQQM LADDKADMVR EAVVKSLGVI MGYIDDPDKY SQGFELMLLS
     LGDPSERVVS ATHQVFIPAF AAWCTELGNL QSQLIPSLLT RIEKLLKQGE YGLDEHKLHM
     YLSALQSLIP SLFAVLLQNA PFTSRVKLQG DVPPIEVTRF PRPASPLQDV ATIVGSREQL
     AVLLHLYDHQ LQHEGTTGWD SLLWVVNQFL PQIIDIVGRI NVTSSTCVHE FSRFFWRLCR
     TFGKIFTNTK VKPQFQEILR LSEENVDATA GNGILTKATV PIYATGVLTC YNQEEDRKLL
     VGFLEDVMTT LSLSHAPLDS LKASFVELGA NPAYHELLLT VLWYGVVHTS ALVRCTAARM
     FELLVKGVNE TLVAQRVVPA LITLSSDPEI SVRISTIPAF GTIMETVTQK ELLERVKMQL
     ASFLEDPQYQ DQHSLHMEII KTFGRVGPNA EPRFRDEFVL PHLHKLALCN NQQTVESKRI
     DIATQLFEAY SALSCCFISE ELMVNHFLPG LRCLRTDMEQ LSPEHEVILS SMIKECEIKV
     ENKGIGEAQG SISIAASLVG EDAKTKFLSK MGQLTTSGAM LANVFQRKK