ID   RELD1_HUMAN             Reviewed;         526 AA.
AC   A0A1B0GV85;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 2.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Reelin domain-containing protein 1 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=REELD1 {ECO:0000312|HGNC:HGNC:53638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-319.
RX   PubMed=11752456; DOI=10.1073/pnas.241522398;
RA   Xu X.R., Huang J., Xu Z.G., Qian B.Z., Zhu Z.D., Yan Q., Cai T., Zhang X.,
RA   Xiao H.S., Qu J., Liu F., Huang Q.H., Cheng Z.H., Li N.G., Du J.J., Hu W.,
RA   Shen K.T., Lu G., Fu G., Zhong M., Xu S.H., Gu W.Y., Huang W., Zhao X.T.,
RA   Hu G.X., Gu J.R., Chen Z., Han Z.G.;
RT   "Insight into hepatocellular carcinogenesis at transcriptome level by
RT   comparing gene expression profiles of hepatocellular carcinoma with those
RT   of corresponding noncancerous liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:15089-15094(2001).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AC097372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471056; EAX05028.1; -; Genomic_DNA.
DR   EMBL; AV698927; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS87268.1; -.
DR   AlphaFoldDB; A0A1B0GV85; -.
DR   SMR; A0A1B0GV85; -.
DR   BioMuta; ENSG00000250673; -.
DR   PeptideAtlas; A0A1B0GV85; -.
DR   Ensembl; ENST00000623665.2; ENSP00000510273.1; ENSG00000250673.3.
DR   Ensembl; ENST00000636502.1; ENSP00000490412.2; ENSG00000250673.3.
DR   MANE-Select; ENST00000623665.2; ENSP00000510273.1; NM_001354631.1; NP_001341560.1.
DR   GeneCards; REELD1; -.
DR   HGNC; HGNC:53638; REELD1.
DR   HPA; ENSG00000250673; Low tissue specificity.
DR   neXtProt; NX_A0A1B0GV85; -.
DR   OpenTargets; ENSG00000250673; -.
DR   VEuPathDB; HostDB:ENSG00000250673; -.
DR   GeneTree; ENSGT00940000163277; -.
DR   OMA; DMQPKHI; -.
DR   Pharos; A0A1B0GV85; Tdark.
DR   PRO; PR:A0A1B0GV85; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; A0A1B0GV85; protein.
DR   Bgee; ENSG00000250673; Expressed in granulocyte and 90 other tissues.
DR   ExpressionAtlas; A0A1B0GV85; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   CDD; cd08544; Reeler; 1.
DR   Gene3D; 2.60.40.4060; -; 1.
DR   InterPro; IPR002861; Reeler_dom.
DR   InterPro; IPR042307; Reeler_sf.
DR   Pfam; PF02014; Reeler; 1.
DR   PROSITE; PS51019; REELIN; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..526
FT                   /note="Reelin domain-containing protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5010648591"
FT   TOPO_DOM        24..443
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        444..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        463..526
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          24..179
FT                   /note="Reelin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00363"
FT   REGION          242..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  56837 MW;  FBA2EC75620E59D7 CRC64;
     MRMQAALVGW ACTTLCLASC SSAFSHGAST VACDDMQPKH IQAQPQHQDS HHITIHTHRT
     SYAPGDKIPV TVRSSRDFMG FLLQARRVSD HQIAGTFVLI PPHSKLMTCF QEADAVTHSD
     KSLKRNLSFV WKAPAQPVGD IKFLLSVVQS YFVYWARIES SVVSQQTHSS AHSDDRMEPR
     LLMPNLHQRL GDVEGAAPAP RTPITLPQQH THVFAVALPG AAEEDNLDPV PASIWVTKFP
     GDAETLSQPS SHTATEGSIN QQPSGDSNPT LEPSLEVHRL ERLVALKRVS SESFASSLST
     HHRTQDDPSF DSLETCLSSD GGEQDKTKAS NRTVTQPPLS TVQLTYPQCL WSSETFTGNG
     VRASNPIPVL QTSGTSGLPA AGDQSEASRA SASFLPQSKH KELRAGKGNG EGGVGYPRQT
     NPRPDIGLEG AQAPLGIQLR TPQLGILLCL SATLGMALAA GLRYLHTQYC HQQTEVSFSE
     PASDAVARSN SGETVHVRKI GENSFVLVQA EYNWITPSVG SKKTVL