ID   RELE1_CAUVC             Reviewed;          93 AA.
AC   Q9AA09;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Toxin RelE1;
GN   Name=relE1; OrderedLocusNames=CC_0802;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS A TOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       toxic effect is neutralized by coexpression with cognate antitoxin
CC       RelB1 but no other ParD or RelB antitoxin.
CC       {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype when deleted singly or as
CC       the relBE1 operon. {ECO:0000269|PubMed:20487277}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; AE005673; AAK22787.1; -; Genomic_DNA.
DR   PIR; G87348; G87348.
DR   RefSeq; NP_419619.1; NC_002696.2.
DR   RefSeq; WP_010918687.1; NC_002696.2.
DR   AlphaFoldDB; Q9AA09; -.
DR   SMR; Q9AA09; -.
DR   STRING; 190650.CC_0802; -.
DR   EnsemblBacteria; AAK22787; AAK22787; CC_0802.
DR   KEGG; ccr:CC_0802; -.
DR   eggNOG; COG3668; Bacteria.
DR   HOGENOM; CLU_147162_13_0_5; -.
DR   OMA; RVIIARI; -.
DR   BioCyc; CAULO:CC0802-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   Pfam; PF05016; ParE_toxin; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..93
FT                   /note="Toxin RelE1"
FT                   /id="PRO_0000408374"
SQ   SEQUENCE   93 AA;  10486 MW;  2D1DC278A0B14C46 CRC64;
     MTFTVLVSVR AKRDFNRLIV WLVERDPRAA ARLGPLLEAA LDSLTEAPSR GRSVGPTTRE
     ISIPFGQSAY VIRYRLLGSS VHVTRIWHGL EQR