ID   RELE1_METJA             Reviewed;          90 AA.
AC   Q60374;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Putative toxin RelE1;
GN   Name=relE1; OrderedLocusNames=MJ0071;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       cognate antitoxin is RelB1 (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98049.1; -; Genomic_DNA.
DR   PIR; G64308; G64308.
DR   RefSeq; WP_010869563.1; NC_000909.1.
DR   AlphaFoldDB; Q60374; -.
DR   SMR; Q60374; -.
DR   STRING; 243232.MJ_0071; -.
DR   EnsemblBacteria; AAB98049; AAB98049; MJ_0071.
DR   GeneID; 1450910; -.
DR   KEGG; mja:MJ_0071; -.
DR   eggNOG; arCOG01665; Archaea.
DR   HOGENOM; CLU_155761_6_2_2; -.
DR   InParanoid; Q60374; -.
DR   OMA; FRVQYVV; -.
DR   OrthoDB; 125851at2157; -.
DR   PhylomeDB; Q60374; -.
DR   Proteomes; UP000000805; Chromosome.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   Pfam; PF05016; ParE_toxin; 1.
DR   SUPFAM; SSF143011; SSF143011; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..90
FT                   /note="Putative toxin RelE1"
FT                   /id="PRO_0000106679"
SQ   SEQUENCE   90 AA;  10851 MW;  78902F645671F70A CRC64;
     MKFNVEIHKR VLKDLKDLPP SNLKKFKELI ETLKTNPIPK EKFDIKRLKG SDEVYRVRIG
     KFRVQYVVLW DDRIIIIRKI SRREGAYKNP