ID   RELE2_CAUVC             Reviewed;          88 AA.
AC   Q9A5D7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Toxin RelE2;
GN   Name=relE2; OrderedLocusNames=CC_2513;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS A TOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       toxic effect is neutralized by coexpression with cognate antitoxin
CC       RelB2 but no other ParD or RelB antitoxin.
CC       {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype when deleted singly or as
CC       the relBE2 operon. {ECO:0000269|PubMed:20487277}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; AE005673; AAK24484.1; -; Genomic_DNA.
DR   PIR; H87560; H87560.
DR   RefSeq; NP_421316.1; NC_002696.2.
DR   AlphaFoldDB; Q9A5D7; -.
DR   SMR; Q9A5D7; -.
DR   STRING; 190650.CC_2513; -.
DR   EnsemblBacteria; AAK24484; AAK24484; CC_2513.
DR   KEGG; ccr:CC_2513; -.
DR   eggNOG; COG3668; Bacteria.
DR   HOGENOM; CLU_147162_11_0_5; -.
DR   OMA; HIVRIRH; -.
DR   BioCyc; CAULO:CC2513-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   Pfam; PF05016; ParE_toxin; 1.
DR   TIGRFAMs; TIGR02385; RelE_StbE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..88
FT                   /note="Toxin RelE2"
FT                   /id="PRO_0000408375"
SQ   SEQUENCE   88 AA;  9977 MW;  86ADF62A7D0EB3C0 CRC64;
     MAQVVWTWRA LADLTAIRDY IGQFSPLAAQ RMALRLKTAA DSLAEYPERG RLATATLREL
     VVVPPYVIRY YVADGLVHIV RIRHAARL