ID   RELE4_CAUVC             Reviewed;         107 AA.
AC   Q9A3S1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Toxin RelE4;
GN   Name=relE4; OrderedLocusNames=CC_3131;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS A TOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       toxic effect is neutralized by coexpression with cognate antitoxin
CC       RelB4 but no other ParD or RelB antitoxin.
CC       {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype when deleted singly or as
CC       the relBE4 operon. {ECO:0000269|PubMed:20487277}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; AE005673; AAK25093.1; -; Genomic_DNA.
DR   PIR; A87637; A87637.
DR   RefSeq; NP_421925.1; NC_002696.2.
DR   RefSeq; WP_010920967.1; NC_002696.2.
DR   AlphaFoldDB; Q9A3S1; -.
DR   SMR; Q9A3S1; -.
DR   STRING; 190650.CC_3131; -.
DR   EnsemblBacteria; AAK25093; AAK25093; CC_3131.
DR   KEGG; ccr:CC_3131; -.
DR   PATRIC; fig|190650.5.peg.3141; -.
DR   eggNOG; COG3668; Bacteria.
DR   HOGENOM; CLU_147162_11_0_5; -.
DR   OMA; PYPYLIF; -.
DR   BioCyc; CAULO:CC3131-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   Pfam; PF05016; ParE_toxin; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..107
FT                   /note="Toxin RelE4"
FT                   /id="PRO_0000408377"
SQ   SEQUENCE   107 AA;  11769 MW;  03AC05235E0F7912 CRC64;
     MAQDVGHAAP DTATIFVAQV VWTQRAMADV YAIVGHISEQ SRPLAAQRLA KRLFDTGASL
     ATYPERGRVS TQGRREIVAI SPYVLRYRIV GDRVVIGSVR HGARRPI