ID   RELE4_METJA             Reviewed;          94 AA.
AC   Q58573;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Putative toxin RelE4;
GN   Name=relE4; OrderedLocusNames=MJ1173;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Its
CC       cognate antitoxin is RelB4 (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99176.1; -; Genomic_DNA.
DR   PIR; D64446; D64446.
DR   RefSeq; WP_010870686.1; NC_000909.1.
DR   AlphaFoldDB; Q58573; -.
DR   SMR; Q58573; -.
DR   STRING; 243232.MJ_1173; -.
DR   EnsemblBacteria; AAB99176; AAB99176; MJ_1173.
DR   GeneID; 1452071; -.
DR   KEGG; mja:MJ_1173; -.
DR   eggNOG; arCOG02414; Archaea.
DR   HOGENOM; CLU_155761_4_0_2; -.
DR   InParanoid; Q58573; -.
DR   OMA; HIDSHFV; -.
DR   OrthoDB; 113687at2157; -.
DR   PhylomeDB; Q58573; -.
DR   Proteomes; UP000000805; Chromosome.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR007712; RelE/ParE_toxin.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR004386; Toxin_YafQ-like.
DR   Pfam; PF05016; ParE_toxin; 1.
DR   SUPFAM; SSF143011; SSF143011; 1.
DR   TIGRFAMs; TIGR02385; RelE_StbE; 1.
DR   TIGRFAMs; TIGR00053; TIGR00053; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..94
FT                   /note="Putative toxin RelE4"
FT                   /id="PRO_0000107200"
SQ   SEQUENCE   94 AA;  11450 MW;  85FDCBCD4A8E4A05 CRC64;
     MYEIEIMPSL DKILQKLSKR DKKKLKAILK KMEEITQNPH HYKNLRHPLN DFKRVHIDKS
     FVLVFTVDEN NKTVIFVDFD HHDNIYKKKK LFKD