RELE_SHIFL
ID RELE_SHIFL Reviewed; 95 AA.
AC P0C078; P07008;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=mRNA interferase RelE;
DE EC=3.1.-.-;
DE AltName: Full=Endoribonuclease RelE;
DE AltName: Full=Toxin RelE;
GN Name=relE; Synonyms=relE1; OrderedLocusNames=SF1548, S1669;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
RN [3]
RP POSSIBLE FUNCTION.
RC STRAIN=301 / Serotype 2a, and ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=15718296; DOI=10.1093/nar/gki201;
RA Pandey D.P., Gerdes K.;
RT "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT host-associated prokaryotes.";
RL Nucleic Acids Res. 33:966-976(2005).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. A
CC sequence-specific, ribosome-dependent mRNA endoribonuclease that
CC inhibits translation during amino acid starvation (the stringent
CC response). Acts by cleaving mRNA with high codon specificity in the
CC ribosomal A site between positions 2 and 3. Acts with RelB as a
CC corepressor of relBE transcription (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a RelE(2)-RelB(2) heterotetramer. RelE occupies
CC the A site of the 70S ribosome. RelB inhibits its endonuclease activity
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RelE toxin family. {ECO:0000305}.
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DR EMBL; AE005674; AAN43137.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP17028.1; -; Genomic_DNA.
DR RefSeq; NP_707430.1; NC_004337.2.
DR RefSeq; WP_000323025.1; NZ_WPGV01000221.1.
DR AlphaFoldDB; P0C078; -.
DR BMRB; P0C078; -.
DR SMR; P0C078; -.
DR STRING; 198214.SF1548; -.
DR EnsemblBacteria; AAN43137; AAN43137; SF1548.
DR EnsemblBacteria; AAP17028; AAP17028; S1669.
DR GeneID; 1024736; -.
DR GeneID; 67375339; -.
DR KEGG; sfl:SF1548; -.
DR KEGG; sfx:S1669; -.
DR PATRIC; fig|198214.7.peg.1830; -.
DR HOGENOM; CLU_155761_0_1_6; -.
DR OMA; GHADRYK; -.
DR OrthoDB; 2036672at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2310.20; -; 1.
DR InterPro; IPR007712; RelE/ParE_toxin.
DR InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR Pfam; PF05016; ParE_toxin; 1.
DR SUPFAM; SSF143011; SSF143011; 1.
DR TIGRFAMs; TIGR02385; RelE_StbE; 1.
PE 3: Inferred from homology;
KW Endonuclease; Hydrolase; Nuclease; Reference proteome; Repressor;
KW RNA-binding; rRNA-binding; Stress response; Toxin-antitoxin system;
KW Transcription; Transcription regulation.
FT CHAIN 1..95
FT /note="mRNA interferase RelE"
FT /id="PRO_0000097246"
SQ SEQUENCE 95 AA; 11225 MW; F516B2E7A437CCEC CRC64;
MAYFLDFDER ALKEWRKLGS TVREQLKKKL VEVLESPRIE ANKLRGMPDC YKIKLRSSGY
RLVYQVIDEK VVVFVISVGK RERSEVYSEA VKRIL
