ID   RELH_RABIT              Reviewed;         178 AA.
AC   P51456;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Relaxin-like protein SQ10;
DE   Contains:
DE     RecName: Full=Relaxin-like protein SQ10 B chain;
DE   Contains:
DE     RecName: Full=Relaxin-like protein SQ10 A chain;
DE   Flags: Precursor;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 21-32; 54-77 AND
RP   120-128.
RC   TISSUE=Tracheobronchial epithelium;
RX   PubMed=1339318;
RA   Jetten A.M., Bernacki S.H., Floyd E.E., Saunders N.A., Pieniazek J.,
RA   Lotan R.;
RT   "Expression of a preprorelaxin-like gene during squamous differentiation of
RT   rabbit tracheobronchial epithelial cells and its suppression by retinoic
RT   acid.";
RL   Cell Growth Differ. 3:549-556(1992).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: During squamous cell differentiation. Repressed by retinoic
CC       acid.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; S45940; AAB23648.1; -; mRNA.
DR   PIR; A49014; A49014.
DR   RefSeq; NP_001075789.1; NM_001082320.1.
DR   AlphaFoldDB; P51456; -.
DR   STRING; 9986.ENSOCUP00000024474; -.
DR   GeneID; 100009160; -.
DR   KEGG; ocu:100009160; -.
DR   CTD; 6013; -.
DR   eggNOG; ENOG502TH8D; Eukaryota.
DR   OrthoDB; 1331287at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022421; Relaxin.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02004; RELAXIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:1339318"
FT   PEPTIDE         21..52
FT                   /note="Relaxin-like protein SQ10 B chain"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016127"
FT   PROPEP          54..150
FT                   /note="Connecting peptide"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016128"
FT   PEPTIDE         155..178
FT                   /note="Relaxin-like protein SQ10 A chain"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016129"
FT   DISULFID        34..165
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..178
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        164..169
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   178 AA;  20294 MW;  F6A54D98A6B53211 CRC64;
     MPALLFYLLG FCLLQGQVTG RVTYEWMMEN VKICRNDFVR TAIEVCGHVH LERESPSPEN
     PFLSSGPAAE TVPSSIKKDA ENANTMLESI PNLPQELTAT LFEKQPSKLY LQYLPTLKKS
     NVSFEEFKKI IQNIQRGVQG SSASESNTFS RKKRQFSESL PEECCKYGCP RYYLLMYC