ID   RELL1_BOVIN             Reviewed;         271 AA.
AC   Q08DP3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=RELT-like protein 1;
DE   Flags: Precursor;
GN   Name=RELL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces activation of MAPK14/p38 cascade, when overexpressed.
CC       Induces apoptosis, when overexpressed. {ECO:0000250|UniProtKB:Q8IUW5}.
CC   -!- SUBUNIT: Interacts with RELT, RELL2, OXSR1 and PLSCR1.
CC       {ECO:0000250|UniProtKB:Q8IUW5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IUW5};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8IUW5}.
CC   -!- SIMILARITY: Belongs to the RELT family. {ECO:0000305}.
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DR   EMBL; BC123636; AAI23637.1; -; mRNA.
DR   RefSeq; NP_001071566.1; NM_001078098.1.
DR   AlphaFoldDB; Q08DP3; -.
DR   STRING; 9913.ENSBTAP00000005668; -.
DR   PaxDb; Q08DP3; -.
DR   Ensembl; ENSBTAT00000005668; ENSBTAP00000005668; ENSBTAG00000004329.
DR   GeneID; 768210; -.
DR   KEGG; bta:768210; -.
DR   CTD; 768211; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004329; -.
DR   VGNC; VGNC:33860; RELL1.
DR   eggNOG; ENOG502R0TD; Eukaryota.
DR   GeneTree; ENSGT00940000159709; -.
DR   HOGENOM; CLU_084225_0_0_1; -.
DR   InParanoid; Q08DP3; -.
DR   OMA; KNICTRC; -.
DR   OrthoDB; 1464869at2759; -.
DR   TreeFam; TF332339; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000004329; Expressed in abomasum and 102 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISS:UniProtKB.
DR   InterPro; IPR042315; RELL1.
DR   InterPro; IPR022248; TNF_rcpt_RELT.
DR   PANTHER; PTHR31037; PTHR31037; 1.
DR   Pfam; PF12606; RELT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Phosphoprotein; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..271
FT                   /note="RELT-like protein 1"
FT                   /id="PRO_0000323589"
FT   TOPO_DOM        24..57
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          27..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..166
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         109
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT   MOD_RES         114
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT   MOD_RES         247
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUW5"
SQ   SEQUENCE   271 AA;  29247 MW;  7784AEADC33B339D CRC64;
     MAPRGLPGSA VLAAAVFVGG AVSSPLVRSD HSGSHPLPSK TETTPSPTNN NGNGHPEYIA
     YALVPVFFVM GLFGVLICHL LKKKGYRCTT EAEQDVEGEK VEKIELNDSV NENSDTVGQI
     VQYIMKNEAN VDILAAMVED NNVCDPESPV TPSTPGSPPV SPGPLSPGVT PGKHICGHHL
     HTVGGPVERD VCHRCRHKRW HFIKPTNKSK EGRPRRQGEV TVLSVGRFRV TKVEPKSNQK
     ERRSLMSVSG TDSVNGEVPV TPVKRQQSDS E