RELL1_MOUSE
ID RELL1_MOUSE Reviewed; 272 AA.
AC Q8K2J7; Q3TVW8; Q3UZH6; Q8R3S5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=RELT-like protein 1;
DE Flags: Precursor;
GN Name=Rell1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, Czech II, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Induces activation of MAPK14/p38 cascade, when overexpressed.
CC Induces apoptosis, when overexpressed. {ECO:0000250|UniProtKB:Q8IUW5}.
CC -!- SUBUNIT: Interacts with RELT, RELL2, OXSR1 and PLSCR1.
CC {ECO:0000250|UniProtKB:Q8IUW5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IUW5};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8IUW5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2J7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2J7-2; Sequence=VSP_032026;
CC -!- SIMILARITY: Belongs to the RELT family. {ECO:0000305}.
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DR EMBL; AK133845; BAE21881.1; -; mRNA.
DR EMBL; AK140108; BAE24240.1; -; mRNA.
DR EMBL; AK159944; BAE35500.1; -; mRNA.
DR EMBL; AK161061; BAE36178.1; -; mRNA.
DR EMBL; BC024679; AAH24679.1; -; mRNA.
DR EMBL; BC031198; AAH31198.2; -; mRNA.
DR EMBL; BC066137; AAH66137.2; -; mRNA.
DR EMBL; BC066160; AAH66160.2; -; mRNA.
DR CCDS; CCDS39093.1; -. [Q8K2J7-1]
DR RefSeq; NP_666035.2; NM_145923.4. [Q8K2J7-1]
DR RefSeq; XP_006503684.1; XM_006503621.3. [Q8K2J7-1]
DR AlphaFoldDB; Q8K2J7; -.
DR STRING; 10090.ENSMUSP00000118125; -.
DR iPTMnet; Q8K2J7; -.
DR PhosphoSitePlus; Q8K2J7; -.
DR SwissPalm; Q8K2J7; -.
DR EPD; Q8K2J7; -.
DR jPOST; Q8K2J7; -.
DR MaxQB; Q8K2J7; -.
DR PaxDb; Q8K2J7; -.
DR PeptideAtlas; Q8K2J7; -.
DR PRIDE; Q8K2J7; -.
DR ProteomicsDB; 253110; -. [Q8K2J7-1]
DR ProteomicsDB; 253111; -. [Q8K2J7-2]
DR Antibodypedia; 2874; 10 antibodies from 7 providers.
DR DNASU; 100532; -.
DR Ensembl; ENSMUST00000154169; ENSMUSP00000118125; ENSMUSG00000047881. [Q8K2J7-1]
DR GeneID; 100532; -.
DR KEGG; mmu:100532; -.
DR UCSC; uc008xmh.1; mouse. [Q8K2J7-1]
DR CTD; 768211; -.
DR MGI; MGI:2140767; Rell1.
DR VEuPathDB; HostDB:ENSMUSG00000047881; -.
DR eggNOG; ENOG502R0TD; Eukaryota.
DR GeneTree; ENSGT00940000159709; -.
DR HOGENOM; CLU_084225_0_0_1; -.
DR InParanoid; Q8K2J7; -.
DR OMA; KNICTRC; -.
DR PhylomeDB; Q8K2J7; -.
DR TreeFam; TF332339; -.
DR BioGRID-ORCS; 100532; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Rell1; mouse.
DR PRO; PR:Q8K2J7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8K2J7; protein.
DR Bgee; ENSMUSG00000047881; Expressed in parotid gland and 247 other tissues.
DR ExpressionAtlas; Q8K2J7; baseline and differential.
DR Genevisible; Q8K2J7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISS:UniProtKB.
DR InterPro; IPR042315; RELL1.
DR InterPro; IPR022248; TNF_rcpt_RELT.
DR PANTHER; PTHR31037; PTHR31037; 1.
DR Pfam; PF12606; RELT; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Coiled coil; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..272
FT /note="RELT-like protein 1"
FT /id="PRO_0000323591"
FT TOPO_DOM 24..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..114
FT /evidence="ECO:0000255"
FT COMPBIAS 153..167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT MOD_RES 245
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT MOD_RES 248
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUW5"
FT VAR_SEQ 1..70
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032026"
SQ SEQUENCE 272 AA; 29351 MW; 3029F065E2BC3C69 CRC64;
MALWGLPGSA VLAASVFVGG AVSSPLVAAD NTGSHTLHSR AETTPSSPTN NPGNGHPEYI
AYVLVPVFFV MGLLGVLICH LLKKKGYRCT TEAEQEVEEE KVEKIELNDS INENSDTVGQ
IVQYIMKNEA NADILKAMVA DNSVGDIESP VTPSTPGSPP VSPGPLSPGA TPGKHVCGHH
LHTVGGVVER DVCQRCRHKR WHFIKPTNKT KEGRPRRQGE VTVLSVGRFR VTKVEHKSNQ
KERRSLMSVS GIESVNGDVP ATPVKRERSD TE
