RELL2_BOVIN
ID RELL2_BOVIN Reviewed; 303 AA.
AC Q2KI80;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=RELT-like protein 2;
GN Name=RELL2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Kidney;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Induces activation of MAPK14/p38 cascade, when overexpressed.
CC Induces apoptosis, when overexpressed. {ECO:0000250|UniProtKB:Q8NC24}.
CC -!- SUBUNIT: Interacts with RELT, RELL1, OXSR1, PLSCR1 AND TRAF2.
CC {ECO:0000250|UniProtKB:Q8NC24}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NC24};
CC Single-pass membrane protein {ECO:0000250|UniProtKB:Q8NC24}.
CC -!- SIMILARITY: Belongs to the RELT family. {ECO:0000305}.
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DR EMBL; BC112736; AAI12737.1; -; mRNA.
DR RefSeq; NP_001039768.1; NM_001046303.1.
DR RefSeq; XP_005209518.1; XM_005209461.3.
DR RefSeq; XP_015327739.1; XM_015472253.1.
DR RefSeq; XP_015327740.1; XM_015472254.1.
DR AlphaFoldDB; Q2KI80; -.
DR SMR; Q2KI80; -.
DR STRING; 9913.ENSBTAP00000023093; -.
DR PaxDb; Q2KI80; -.
DR Ensembl; ENSBTAT00000023093; ENSBTAP00000023093; ENSBTAG00000017371.
DR GeneID; 529327; -.
DR KEGG; bta:529327; -.
DR CTD; 285613; -.
DR VEuPathDB; HostDB:ENSBTAG00000017371; -.
DR VGNC; VGNC:33861; RELL2.
DR eggNOG; ENOG502RZW4; Eukaryota.
DR GeneTree; ENSGT00940000160541; -.
DR HOGENOM; CLU_074130_0_0_1; -.
DR InParanoid; Q2KI80; -.
DR OMA; RIVQCII; -.
DR OrthoDB; 1464869at2759; -.
DR TreeFam; TF332339; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000017371; Expressed in retina and 99 other tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IBA:GO_Central.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISS:UniProtKB.
DR InterPro; IPR042313; RELL2.
DR InterPro; IPR022248; TNF_rcpt_RELT.
DR PANTHER; PTHR31481; PTHR31481; 1.
DR Pfam; PF12606; RELT; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..303
FT /note="RELT-like protein 2"
FT /id="PRO_0000249844"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 46..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BRJ3"
SQ SEQUENCE 303 AA; 32269 MW; 3E54767206D88227 CRC64;
MSEPQPDLEP PQHGLYMLFL LVLVFFLMGL VGFMICHVLK KKGYRCRTSR GSEPDDAQLQ
PPEDDDMNED TVERIVRCII QNEANAEALK EMLGDSEGEG TVQLSSVDAT SSLQDGAPSH
HHTVHLGSSA PCIHCSRNKR PPLVRQGRSK EGKSRPRPGE TTVFSVGRFR VTHIEKRYGL
HEHRDGSPTD RSWGSGGGQD PGGGQGPGGG QPRTGMPAIE SLPPERPQPP ALASTPMQNG
GLRDSSRVPR ALEGNPGASA EPMLGAGGRG PSPGPARKEA NGQPSKQDTS DHQVSPPRGA
GGV
